Synthesis of 6-and 7-propargyloxy derivatives of 4-(3-fluoroanilino)-quinazoline

被引：2
|
作者：
Pham, Helen Trinh [1 ]
Hanson, Robert N. [1 ]
Olmsted, Sandra L. [2 ]
Kozhushnyan, Anton [1 ]
Visentin, Adam [1 ]
Weglinsky, Paul J. [1 ]
Massero, Chris [1 ]
Bailey, Kristen [1 ]
机构：
[1] Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA
[2] Augsburg Coll, Dept Chem, Minneapolis, MN 55454 USA
来源：
TETRAHEDRON LETTERS | 2011年 / 52卷 / 10期
关键词：
Anilinoquinazoline; Tyrosine kinase inhibitors; Bifunctional derivatives; TYROSINE KINASE INHIBITORS; COMBI-TARGETING CONCEPT; PYRROLOBENZODIAZEPINE DIMERS; ANTITUMOR-ACTIVITY; GEFITINIB IRESSA; CANCER-THERAPY; POTENT; DESIGN; ERLOTINIB; CYCLOADDITIONS;
D O I：
10.1016/j.tetlet.2010.11.107
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The preparation of the novel isomeric 6- and 7-propargyloxy derivatives of 4-(3-fluoroanilino)-quinazoline was achieved using a six-step process. An alternate method to the 7-propargyloxy derivative and analogous 7-propargyloxy containing compounds is also described. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1053 / 1056
页数：4
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