Synthesis of 6-and 7-propargyloxy derivatives of 4-(3-fluoroanilino)-quinazoline

被引：2

作者：

Pham, Helen Trinh ^{[1
]}

Hanson, Robert N. ^{[1
]}

Olmsted, Sandra L. ^{[2
]}

Kozhushnyan, Anton ^{[1
]}

Visentin, Adam ^{[1
]}

Weglinsky, Paul J. ^{[1
]}

Massero, Chris ^{[1
]}

Bailey, Kristen ^{[1
]}

机构：

[1] Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA

[2] Augsburg Coll, Dept Chem, Minneapolis, MN 55454 USA

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 10期

关键词：

Anilinoquinazoline; Tyrosine kinase inhibitors; Bifunctional derivatives; TYROSINE KINASE INHIBITORS; COMBI-TARGETING CONCEPT; PYRROLOBENZODIAZEPINE DIMERS; ANTITUMOR-ACTIVITY; GEFITINIB IRESSA; CANCER-THERAPY; POTENT; DESIGN; ERLOTINIB; CYCLOADDITIONS;

D O I：

10.1016/j.tetlet.2010.11.107

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of the novel isomeric 6- and 7-propargyloxy derivatives of 4-(3-fluoroanilino)-quinazoline was achieved using a six-step process. An alternate method to the 7-propargyloxy derivative and analogous 7-propargyloxy containing compounds is also described. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1053 / 1056

页数：4

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