Recent Advances in Functional Carbon Quantum Dots for Antitumour

被引:20
作者
Cai, Rong [1 ]
Xiao, Long [1 ]
Liu, Meixiu [1 ]
Du, Fengyi [2 ]
Wang, Zhirong [1 ]
机构
[1] Nanjing Univ Chinese Med, Zhangjiagang TCM Hosp, Cent Lab, Suzhou 215600, Jiangsu, Peoples R China
[2] Sch Med, Zhenjiang 212013, Jiangsu, Peoples R China
来源
INTERNATIONAL JOURNAL OF NANOMEDICINE | 2021年 / 16卷
关键词
CQDs; antitumour; drug delivery; phototherapy; CELL LUNG-CANCER; PHOTODYNAMIC THERAPY; DRUG-DELIVERY; IN-VITRO; LIPOSOMAL DOXORUBICIN; SELECTIVE DETECTION; HIGHLY FLUORESCENT; MESOPOROUS SILICA; STEP SYNTHESIS; BREAST-CANCER;
D O I
10.2147/IJN.S334012
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Carbon quantum dots (CQDs) are an emerging class of quasi-zero-dimensional photoluminescent nanomaterials with particle sizes less than 10 nm. Owing to their favourable water dispersion, strong chemical inertia, stable optical performance, and good biocompatibility, CQDs have become prominent in biomedical fields. CQDs can be fabricated by "top-down" and "bottom-up" methods, both of which involve oxidation, carbonization, pyrolysis and polymerization. The functions of CQDs include biological imaging, biosensing, drug delivery, gene carrying, antimicrobial performance, photothermal ablation and so on, which enable them to be utilized in antitumour applications. The purpose of this review is to summarize the research progress of CQDs in antitumour applications from preparation and characterization to application prospects. Furthermore, the challenges and opportunities of CQDs are discussed along with future perspectives for precise individual therapy of tumours.
引用
收藏
页码:7195 / 7229
页数:35
相关论文
共 254 条
  • [71] On-off-on nanosensors of carbon quantum dots derived from coal tar pitch for the detection of Cu2+, Fe3+, and L-ascorbic acid
    Hu, Chaoshuai
    Zhu, Yaming
    Zhao, Xuefei
    [J]. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2021, 250
  • [72] Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases
    Hu, Zheng
    Li, Zan
    Ma, Zhicheng
    Curtis, Christina
    [J]. NATURE GENETICS, 2020, 52 (07) : 701 - +
  • [73] Ultrasmall All-In-One Nanodots Formed via Carbon Dot-Mediated and Albumin-Based Synthesis: Multimodal Imaging-Guided and Mild Laser-Enhanced Cancer Therapy
    Hua, Xian-Wu
    Bao, Yan-Wen
    Zeng, Jia
    Wu, Fu-Gen
    [J]. ACS APPLIED MATERIALS & INTERFACES, 2018, 10 (49) : 42077 - 42087
  • [74] Fluorescent Carbon Quantum Dots with Intrinsic Nucleolus-Targeting Capability for Nucleolus Imaging and Enhanced Cytosolic and Nuclear Drug Delivery
    Hua, Xian-Wu
    Bao, Yan-Wen
    Wu, Fu-Gen
    [J]. ACS APPLIED MATERIALS & INTERFACES, 2018, 10 (13) : 10664 - 10677
  • [75] Aggregation-Induced Emission Luminogens Married to 2D Black Phosphorus Nanosheets for Highly Efficient Multimodal Theranostics
    Huang, Jiachang
    He, Benzhao
    Zhang, Zhijun
    Li, Youmei
    Kang, Miaomiao
    Wang, Yuanwei
    Li, Kai
    Wang, Dong
    Tang, Ben Zhong
    [J]. ADVANCED MATERIALS, 2020, 32 (37)
  • [76] Enhanced Near-Infrared-to-Visible Upconversion by Synthetic Control of PbS Nanocrystal Triplet Photosensitizers
    Huang, Zhiyuan
    Xu, Zihao
    Mahboub, Melika
    Liang, Zhiming
    Jaimes, Paulina
    Xia, Pan
    Graham, Kenneth R.
    Tang, Ming L.
    Lian, Tianquan
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019, 141 (25) : 9769 - 9772
  • [77] Activation of Meiosis-Specific Genes Is Associated with Depolyploidization of Human Tumor Cells following Radiation-induced Mitotic Catastrophe
    Ianzini, Fiorenza
    Kosmacek, Elizabeth A.
    Nelson, Elke S.
    Napoli, Eleonora
    Erenpreisa, Jekaterina
    Kalejs, Martins
    Mackey, Michael A.
    [J]. CANCER RESEARCH, 2009, 69 (06) : 2296 - 2304
  • [78] Nucleophilicity and Electrophilicity Parameters for Predicting Absolute Rate Constants of Highly Asynchronous 1,3-Dipolar Cycloadditions of Aryldiazomethanes
    Jangra, Harish
    Chen, Quan
    Fuks, Elina
    Zenz, Ivo
    Mayer, Peter
    Ofial, Armin R.
    Zipse, Hendrik
    Mayr, Herbert
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 140 (48) : 16758 - 16772
  • [79] Synthesis of carbon dots from Hypocrella bambusae for bimodel fluorescence/photoacoustic imaging-guided synergistic photodynamic/photothermal therapy of cancer
    Ji, Qingyan
    Zheng, Xiuli
    Ge, Jiechao
    Liu, Weimin
    Ren, Haohui
    Chen, Shiqing
    Wen, Yongmei
    Zhang, Hongyan
    Wu, Jiasheng
    Wang, Pengfei
    [J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2018, 526 : 302 - 311
  • [80] Green-emitting carbon dot loaded silica nanoparticles coated with DNA-cross-linked hydrogels for sensitive carcinoembryonic antigen detection and effective targeted cancer therapy
    Ji, Xiaoting
    Lv, Haoyuan
    Sun, Xinxin
    Ding, Caifeng
    [J]. CHEMICAL COMMUNICATIONS, 2019, 55 (100) : 15101 - 15104