Recent Advances in Functional Carbon Quantum Dots for Antitumour

被引:20
作者
Cai, Rong [1 ]
Xiao, Long [1 ]
Liu, Meixiu [1 ]
Du, Fengyi [2 ]
Wang, Zhirong [1 ]
机构
[1] Nanjing Univ Chinese Med, Zhangjiagang TCM Hosp, Cent Lab, Suzhou 215600, Jiangsu, Peoples R China
[2] Sch Med, Zhenjiang 212013, Jiangsu, Peoples R China
来源
INTERNATIONAL JOURNAL OF NANOMEDICINE | 2021年 / 16卷
关键词
CQDs; antitumour; drug delivery; phototherapy; CELL LUNG-CANCER; PHOTODYNAMIC THERAPY; DRUG-DELIVERY; IN-VITRO; LIPOSOMAL DOXORUBICIN; SELECTIVE DETECTION; HIGHLY FLUORESCENT; MESOPOROUS SILICA; STEP SYNTHESIS; BREAST-CANCER;
D O I
10.2147/IJN.S334012
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Carbon quantum dots (CQDs) are an emerging class of quasi-zero-dimensional photoluminescent nanomaterials with particle sizes less than 10 nm. Owing to their favourable water dispersion, strong chemical inertia, stable optical performance, and good biocompatibility, CQDs have become prominent in biomedical fields. CQDs can be fabricated by "top-down" and "bottom-up" methods, both of which involve oxidation, carbonization, pyrolysis and polymerization. The functions of CQDs include biological imaging, biosensing, drug delivery, gene carrying, antimicrobial performance, photothermal ablation and so on, which enable them to be utilized in antitumour applications. The purpose of this review is to summarize the research progress of CQDs in antitumour applications from preparation and characterization to application prospects. Furthermore, the challenges and opportunities of CQDs are discussed along with future perspectives for precise individual therapy of tumours.
引用
收藏
页码:7195 / 7229
页数:35
相关论文
共 254 条
  • [91] Liposomal doxorubicin and conventionally fractionated radiotherapy in the treatment of locally advanced non-small-cell lung cancer and head and neck cancer
    Koukourakis, MI
    Koukouraki, S
    Giatromanolaki, A
    Archimandritis, SC
    Skarlatos, J
    Beroukas, K
    Bizakis, JG
    Retalis, G
    Karkavitsas, N
    Helidonis, ES
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (11) : 3512 - 3521
  • [92] Carbon dots based FRET for the detection of DNA damage
    Kudr, Jiri
    Richtera, Lukas
    Xhaxhiu, Kledi
    Hynek, David
    Heger, Zbynek
    Zitka, Ondrej
    Adam, Vojtech
    [J]. BIOSENSORS & BIOELECTRONICS, 2017, 92 : 133 - 139
  • [93] The clinical landscape for AAV gene therapies
    Kuzmin, Dmitry A.
    Shutova, Maria V.
    Johnston, Natalie R.
    Smith, Owen P.
    Fedorin, Vasily V.
    Kukushkin, Yury S.
    van der Loo, Johannes C. M.
    Johnstone, Elaine C.
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2021, 20 (03) : 173 - 174
  • [94] RADIOTHERAPY FOR BRAIN-TUMORS
    LAPERRIERE, NJ
    BERNSTEIN, M
    [J]. CA-A CANCER JOURNAL FOR CLINICIANS, 1994, 44 (02) : 96 - 108
  • [95] One-pot synthesis of carbon dots with intrinsic folic acid for synergistic imaging-guided photothermal therapy of prostate cancer cells
    Le Minh Tu Phan
    Gul, Anam Rana
    Thi Ngoc Le
    Kim, Min Woo
    Kailasa, Suresh Kumar
    Oh, Kyung Taek
    Park, Tae Jung
    [J]. BIOMATERIALS SCIENCE, 2019, 7 (12) : 5187 - 5196
  • [96] Electrochemiluminescent Transistors: A New Strategy toward Light-Emitting Switching Devices
    Lee, Seonjeong
    Lee, Han Ju
    Ji, Yena
    Lee, Keun Hyung
    Hong, Kihyon
    [J]. ADVANCED MATERIALS, 2021, 33 (05)
  • [97] Two-Photon Dual-Emissive Carbon Dot-Based Probe: Deep-Tissue Imaging and Ultrasensitive Sensing of Intracellular Ferric Ions
    Lesani, Pooria
    Singh, Gurvinder
    Viray, Christina
    Ramaswamy, Yogambha
    Zhu, De Ming
    Kingshott, Peter
    Lu, Zufu
    Zreiqat, Hala
    [J]. ACS APPLIED MATERIALS & INTERFACES, 2020, 12 (16) : 18395 - 18406
  • [98] Near-Infrared Excitation/Emission and Multiphoton-Induced Fluorescence of Carbon Dots
    Li, Di
    Jing, Pengtao
    Sun, Lihuan
    An, Yang
    Shan, Xinyan
    Lu, Xinghua
    Zhou, Ding
    Han, Dong
    Shen, Dezhen
    Zhai, Yuechen
    Qu, Songnan
    Zboril, Radek
    Rogach, Andrey L.
    [J]. ADVANCED MATERIALS, 2018, 30 (13)
  • [99] Water-Soluble Fluorescent Carbon Quantum Dots and Photocatalyst Design
    Li, Haitao
    He, Xiaodie
    Kang, Zhenhui
    Huang, Hui
    Liu, Yang
    Liu, Jinglin
    Lian, Suoyuan
    Tsang, Chi Him A.
    Yang, Xiaobao
    Lee, Shuit-Tong
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (26) : 4430 - 4434
  • [100] One-pot synthesis of aqueous soluble and organic soluble carbon dots and their multi-functional applications
    Li, Junfen
    Li, Pengxia
    Wang, Dongxiu
    Dong, Chuan
    [J]. TALANTA, 2019, 202 : 375 - 383