Recent Advances in Functional Carbon Quantum Dots for Antitumour

被引:20
作者
Cai, Rong [1 ]
Xiao, Long [1 ]
Liu, Meixiu [1 ]
Du, Fengyi [2 ]
Wang, Zhirong [1 ]
机构
[1] Nanjing Univ Chinese Med, Zhangjiagang TCM Hosp, Cent Lab, Suzhou 215600, Jiangsu, Peoples R China
[2] Sch Med, Zhenjiang 212013, Jiangsu, Peoples R China
来源
INTERNATIONAL JOURNAL OF NANOMEDICINE | 2021年 / 16卷
关键词
CQDs; antitumour; drug delivery; phototherapy; CELL LUNG-CANCER; PHOTODYNAMIC THERAPY; DRUG-DELIVERY; IN-VITRO; LIPOSOMAL DOXORUBICIN; SELECTIVE DETECTION; HIGHLY FLUORESCENT; MESOPOROUS SILICA; STEP SYNTHESIS; BREAST-CANCER;
D O I
10.2147/IJN.S334012
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Carbon quantum dots (CQDs) are an emerging class of quasi-zero-dimensional photoluminescent nanomaterials with particle sizes less than 10 nm. Owing to their favourable water dispersion, strong chemical inertia, stable optical performance, and good biocompatibility, CQDs have become prominent in biomedical fields. CQDs can be fabricated by "top-down" and "bottom-up" methods, both of which involve oxidation, carbonization, pyrolysis and polymerization. The functions of CQDs include biological imaging, biosensing, drug delivery, gene carrying, antimicrobial performance, photothermal ablation and so on, which enable them to be utilized in antitumour applications. The purpose of this review is to summarize the research progress of CQDs in antitumour applications from preparation and characterization to application prospects. Furthermore, the challenges and opportunities of CQDs are discussed along with future perspectives for precise individual therapy of tumours.
引用
收藏
页码:7195 / 7229
页数:35
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共 254 条
  • [1] Mid-infrared near-field spectroscopy
    Amarie, Sergiu
    Ganz, Thomas
    Keilmann, Fritz
    [J]. OPTICS EXPRESS, 2009, 17 (24): : 21794 - 21801
  • [2] Soft Mode Metal-Linker Dynamics in Carboxylate MOFs Evidenced by Variable-Temperature Infrared Spectroscopy
    Andreeva, Anastasia B.
    Le, Khoa N.
    Chen, Lihaokun
    Kellman, Michael E.
    Hendon, Christopher H.
    Brozek, Carl K.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2020, 142 (45) : 19291 - 19299
  • [3] Hydrothermal synthesis of highly fluorescent and non-toxic carbon dots using Stevia rebaudiana Bertoni
    Ansari, Fatemeh
    Kahrizi, Danial
    [J]. CELLULAR AND MOLECULAR BIOLOGY, 2018, 64 (12) : 32 - 36
  • [4] Design, Synthesis, and Functionalization Strategies of Tailored Carbon Nanodots
    Arcudi, Francesca
    Dordevic, Luka
    Prato, Maurizio
    [J]. ACCOUNTS OF CHEMICAL RESEARCH, 2019, 52 (08) : 2070 - 2079
  • [5] Highly fluorescent nitrogen-doped carbon dots derived from Phyllanthus acidus utilized as a fluorescent probe for label-free selective detection of Fe3+ ions, live cell imaging and fluorescent ink
    Atchudan, Raji
    Edison, Thomas Nesakumar Jebakumar Immanuel
    Aseer, Kanikkai Raja
    Perumal, Suguna
    Karthik, Namachivayam
    Lee, Yong Rok
    [J]. BIOSENSORS & BIOELECTRONICS, 2018, 99 : 303 - 311
  • [6] Nitrogen-doped carbon dots originating from unripe peach for fluorescent bioimaging and electrocatalytic oxygen reduction reaction
    Atchudan, Raji
    Edison, Thomas Nesakumar Jebakumar Immanuel
    Lee, Yong Rok
    [J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2016, 482 : 8 - 18
  • [7] Carbon dots-decorated multiwalled carbon nanotubes nanocomposites as a high-performance electrochemical sensor for detection of H2O2 in living cells
    Bai, Jing
    Sun, Chunhe
    Jiang, Xiue
    [J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2016, 408 (17) : 4705 - 4714
  • [8] Extending Single-Molecule Forster Resonance Energy Transfer (FRET) Range beyond 10 Nanometers in Zero-Mode Waveguides
    Baibakov, Mikhail
    Patra, Satyajit
    Claude, Jean-Benoit
    Moreau, Antonin
    Lumeau, Julien
    Wenger, Jerome
    [J]. ACS NANO, 2019, 13 (07) : 8469 - 8480
  • [9] Multifunctional N-P-doped carbon dots for regulation of apoptosis and autophagy in B16F10 melanoma cancer cells and in vitro imaging applications
    Bajpai, Vivek K.
    Khan, Imran
    Shukla, Shruti
    Kang, Sung-Min
    Aziz, Faisal
    Tripathi, Kumud Malika
    Saini, Deepika
    Cho, Hye-Jin
    Heo, Nam Su
    Sonkar, Sumit K.
    Chen, Lei
    Huh, Yun Suk
    Han, Young-Kyu
    [J]. THERANOSTICS, 2020, 10 (17): : 7841 - 7856