Specific anticancer activity of a new bisabolane sesquiterpene against human leukemia cells inducing differentiation in vitro

被引：5

作者：

Wang, Huan ^{[1
]}

Gao, Huanhuan ^{[1
]}

Wang, Qin ^{[1
]}

Gao, Qingxiang ^{[1
]}

Lin, Changjun ^{[1
]}

机构：

[1] Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Peoples R China

来源：

PHARMAZIE | 2007年 / 62卷 / 09期

关键词：

D O I：

10.1691/ph.2007.9.6788

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A bisabolane sesquiterpene, rel-(1S,4R,5S,6R)-4,5-diacetoxy-6-[(R)-5-hydroxy-1,5-dimethylhex-3-enyl]-3-methylcyclohex-2-enyl]- (Z)-2-methylbut-2-enoate, which was newly isolated from the roots of Leontopodium longifolium, presented specific anticancer activity against human leukemia HL-60 cells, but did not inhibit proliferation of human hepatoma SMMC-7721 cells and human normal hepatocytes L02 cells. Nitroblue tetrazolium (NBT) reduction, phagocytosis of latex beads, and cell electrophoresis all demonstrated that this bisabolane sesquiterpene presented its anticancer activity against human leukemia HL-60 cells in vitro via inducing cell differentiation. Our results may have implications for treatment of human leukemia with the sesquiterpene.

引用

页码：699 / 704

页数：6

共 29 条

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