Genomic landscape of Waldenstrom's macroglobulinemia

被引：1

作者：

Treon, Steven P. ^{[1
,2
]}

Hunter, Zachary R. ^{[1
,2
]}

Branagan, Andrew R. ^{[2
,3
]}

Castillo, Jorge J. ^{[1
,2
]}

机构：

[1] Dana Farber Canc Inst, Bing Ctr Waldenstroms Macroglobulinemia, Boston, MA 02215 USA

[2] Harvard Med Sch, Dept Med, Boston, MA 02215 USA

[3] Massachusetts Gen Hosp, Div Hematol Oncol, Boston, MA 02114 USA

来源：

HEMASPHERE | 2019年 / 3卷

关键词：

MYD88 L265P MUTATION; SURVIVAL; PROGRESSION; RESISTANCE; IBRUTINIB; RISK;

D O I：

10.1097/HS9.0000000000000228

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Take home messages Next-generation sequencing has revealed recurring somatic mutations in Waldenstrom's Macroglobulinemia that include MYD88 (95%-97%), CXCR4 (30%-40%), ARID1A (17%) and CD79B (8%-15%). Deletions involving chromosome 6q are common in MYD88 mutated patients, and include genes that modulate NFKB, BCL2, BTK, and apoptosis. Wild-type MYD88 Waldenstrom's Macroglobulinemia (WM) patients show an increased risk of transformation and death, and exhibit many mutations found in diffuse large B-cell lymphoma. Response to the BTK inhibitor ibrutinib is impacted by both MYD88 and CXCR4 mutation status in WM.

引用

页码：58 / 61

页数：4

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