Synthesis of oxindoles through trifluoromethylation of N-aryl acrylamides by photoredox catalysis

被引：49
作者：
Lu, Maojian [1 ]
Liu, Zhiji [1 ]
Zhang, Jinwang [1 ]
Tian, Yu [1 ]
Qin, Honggui [1 ]
Huang, Mingqiang [1 ]
Hu, Shirong [1 ]
Cai, Shunyou [1 ,2 ]
机构：
[1] Minnan Normal Univ, Sch Chem Chem Engn & Environm, Key Lab Modern Analyt Sci & Separat Technol Fujia, Zhangzhou 363000, Peoples R China
[2] Peking Univ, Shenzhen Grad Sch, Sch Chem Biol & Biotechnol, Key Lab Chem Genom, Shenzhen 518055, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2018年 / 16卷 / 35期
基金：
中国国家自然科学基金;
关键词：
METAL-FREE SYNTHESIS; SODIUM TRIFLUOROMETHANESULFINATE; OXIDATIVE TRIFLUOROMETHYLATION; 3-COMPONENT OXYTRIFLUOROMETHYLATION; UNACTIVATED ALKENES; ACTIVATED ALKENES; RADICAL ADDITIONS; CARBOXYLIC-ACIDS; HIGHLY EFFICIENT; EOSIN Y;
D O I：
10.1039/c8ob01922c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Mild and direct intramolecular oxidative aryltrifluoromethylations of activated alkenes have been established through visible light photocatalysis, affording a range of CF3-containing oxindoles or isoquinolinediones in the presence of an organic fluorophore-type photocatalyst 4CzIPN, oxygen and visible light irradiation under strong oxidant and transition metal free conditions. A variety of frequently encountered functional groups are well tolerated in this transformation.
引用
收藏
页码：6564 / 6568
页数：5
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