General personality dimensions, impairment and treatment response in obsessive-compulsive disorder

被引：10

作者：

Samuels, Jack ^{[1
]}

Bienvenu, O. Joseph ^{[1
]}

Krasnow, Janice ^{[1
]}

Wang, Ying ^{[1
]}

Grados, Marco A. ^{[1
]}

Cullen, Bernadette ^{[1
]}

Goes, Fernando S. ^{[1
]}

Maher, Brion ^{[2
]}

Greenberg, Benjamin D. ^{[3
]}

McLaughlin, Nicole C. ^{[3
]}

Rasmussen, Steven A. ^{[3
]}

Fyer, Abby J. ^{[4
,5
]}

Knowles, James A. ^{[6
]}

McCracken, James T. ^{[7
]}

Piacentini, John ^{[7
]}

Geller, Dan ^{[8
]}

Stewart, S. Evelyn ^{[9
]}

Murphy, Dennis L. ^{[10
]}

Shugart, Yin-Yao ^{[11
]}

Riddle, Mark A. ^{[1
]}

Nestadt, Gerald ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Psychiat & Behav Sci, Sch Med, 550 Broadway 902, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD 21205 USA

[3] Brown Med Sch, Butler Hosp, Dept Psychiat & Human Behav, Providence, RI USA

[4] Columbia Univ, Dept Psychiat, Vagelos Coll Phys & Surg, New York, NY USA

[5] New York State Psychiat Inst & Hosp, Anxiety Disorders Clin, New York, NY 10032 USA

[6] Suny Downstate Med Ctr, Dept Cell Biol, Brooklyn, NY 11203 USA

[7] Univ Calif Los Angeles, Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA

[8] Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA

[9] Univ British Columbia, Fac Med, Dept Psychiat, Vancouver, BC, Canada

[10] NIMH, Lab Clin Sci, NIH, Bethesda, MD 20892 USA

[11] NIMH, Unit Stat Genom, Div Intramural Res, Bethesda, MD 20892 USA

来源：

PERSONALITY AND MENTAL HEALTH | 2020年 / 14卷 / 02期

基金：

美国国家卫生研究院;

关键词：

OCD COLLABORATIVE GENETICS; BIG; 5; PERSONALITY; ANXIETY DISORDERS; 5-FACTOR MODEL; MAJOR DEPRESSION; ASSOCIATION; OUTCOMES; THERAPY; TRAITS; ONSET;

D O I：

10.1002/pmh.1472

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

General personality dimensions are associated with clinical severity and treatment response in individuals with depression and many anxiety disorders, but little is known about these relationships in individuals with obsessive-compulsive disorder (OCD). Individuals in the current study included 705 adults with OCD who had participated in family and genetic studies of the disorder. Participants self-completed the Neuroticism, Extraversion, Openness Personality Inventory or Neuroticism, Extraversion, Openness Five-Factor Inventory-3. Relationships between personality scores, and subjective impairment and OCD treatment response, were evaluated. The odds of subjective impairment increased with (unit increase in) the neuroticism score (odds ratio, OR = 1.03; 95% CI = 1.01-1.04; p < 0.01) and decreased with extraversion scores (OR = 0.98; 95% CI = 0.96-0.99; p < 0.01). The odds of reporting a good response to serotonin/selective serotonin reuptake inhibitors (OR = 1.02; 95% CI = 1.01-1.04; p < 0.01) or cognitive behavioural therapy (OR = 1.03; 95% CI = 1.01-1.05; p < 0.01) increased with the extraversion score. The magnitude of these relationships did not change appreciably after adjusting for other clinical features related to one or more of the personality dimensions. The findings suggest that neuroticism and extraversion are associated with subjective impairment, and that extraversion is associated with self-reported treatment response, in individuals with OCD. (c) 2019 John Wiley & Sons, Ltd.

引用

页码：186 / 198

页数：13

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