Increased VH 11 and VH Q52 gene use by splenic B cells in old mice associated with oligoclonal expansions of CD5+B cells

被引:26
作者
Ben-Yehuda, A
Szabo, P
LeMaoult, J
Manavalan, JS
Weksler, ME
机构
[1] Cornell Univ Med Coll, Div Geriatr & Gerontol, New York, NY 10021 USA
[2] Hadassah Univ Hosp, Dept Med, Geriatr Unit, IL-91010 Jerusalem, Israel
关键词
aging; V-H 11 and V-H Q52 genes; splenic B cells; CD5 + B cells;
D O I
10.1016/S0047-6374(98)00004-9
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
A significant increase in the utilization of the V-H gene families VH11 and Q52 was observed in LPS-stimulated splenic B lymphocytes from aged mice compared to young mice. V-H gene usage was assayed by in situ DNA/RNA hybridization using V-H family-specific and kappa chain probes. The observed age-dependent differences appear to reflect the preferential use of VH11 and Q52 V-H gene use by the CD5 + B lymphocyte subset whose numbers in the spleen increase with age. The increased use of VH11 by splenic cells from old mice is associated with clonal expansions of splenic CD5 + B lymphocytes. (C) 1998 Published by Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:111 / 121
页数:11
相关论文
共 21 条
[1]   BIASED VH GENE-EXPRESSION IN MURINE CD5 B-CELLS RESULTS FROM AGE-DEPENDENT CELLULAR-SELECTION [J].
ANDRADE, L ;
HUETZ, F ;
PONCET, P ;
THOMASVASLIN, V ;
GOODHARDT, M ;
COUTINHO, A .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1991, 21 (09) :2017-2023
[2]  
HARDY RR, 1994, ADV IMMUNOL, V55, P297
[3]   DISTINCTIVE DEVELOPMENTAL ORIGINS AND SPECIFICITIES OF MURINE CD5(+)B CELLS [J].
HARDY, RR ;
CARMACK, CE ;
LI, YS ;
HAYAKAWA, K .
IMMUNOLOGICAL REVIEWS, 1994, 137 :91-118
[4]   DETECTION OF LYMPHOCYTES EXPRESSING HUMAN LYMPHOTROPIC-T VIRUS TYPE-III IN LYMPH-NODES AND PERIPHERAL-BLOOD FROM INFECTED INDIVIDUALS BY INSITU HYBRIDIZATION [J].
HARPER, ME ;
MARSELLE, LM ;
GALLO, RC ;
WONGSTAAL, F .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (03) :772-776
[5]   COMPARISON OF THE FETAL AND ADULT FUNCTIONAL B-CELL REPERTOIRES BY ANALYSIS OF VH GENE FAMILY EXPRESSION [J].
JEONG, HD ;
TEALE, JM .
JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 168 (02) :589-603
[6]  
Kabat E.A., 1987, SEQUENCES PROTEINS I, DOI DOI 10.1016/0003-2697(84)90805-4
[7]  
LeMaoult J, 1997, J IMMUNOL, V159, P3866
[8]   Effect of age on humoral immunity, selection of the B-cell repertoire and B-cell development [J].
LeMaoult, J ;
Szabo, P ;
Weksler, ME .
IMMUNOLOGICAL REVIEWS, 1997, 160 :115-126
[9]  
MICELI R M, 1990, Aging Immunology and Infectious Disease, V2, P153
[10]   T-CELL REPERTOIRE DIVERSITY AND CLONAL EXPANSIONS IN NORMAL AND CLINICAL-SAMPLES [J].
PANNETIER, C ;
EVEN, J ;
KOURILSKY, P .
IMMUNOLOGY TODAY, 1995, 16 (04) :176-181