The structure of ribosome inactivating proteins

被引：46

作者：

Robertus, JD ^{[1
]}

Monzingo, AF ^{[1
]}

机构：

[1] Univ Texas, Dept Chem & Biochem, Inst Biol Mol & Cellulaire, Austin, TX 78712 USA

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2004年 / 4卷 / 05期

关键词：

D O I：

10.2174/1389557043403837

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ribosome Inactivating Proteins, RIPs, depurinate an invariant adenine from the 28S rRNA of eukaryotic ribosomes; they have evolved to near enzymatic perfection for this task. The N-glycosidase fold is conserved in plant and bacterial enzymes. RIPs can form complexes with cell surface recognition proteins that dramatically increase the cytotoxicity of the molecule.

引用

页码：477 / 486

页数：10

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