Validation of the Postnatal Growth and Retinopathy of Prematurity Screening Criteria

被引：63

作者：

Binenbaum, Gil ^{[1
,2
,9
,34
,47
]}

Tomlinson, Lauren A. ^{[1
,9
,34
,47
]}

Campomanes, Alejandra G. de Alba ^{[3
,40
,41
,42
,47
]}

Bell, Edward F. ^{[4
,25
,47
]}

Donohue, Pamela ^{[5
,15
,47
]}

Morrison, David ^{[6
,30
,31
,47
]}

Quinn, Graham E. ^{[1
,2
,34
,47
]}

Repka, Michael X. ^{[7
,15
,47
]}

Rogers, David ^{[8
,21
,47
]}

Yang, Michael B.

Yu, Yinxi ^{[2
,10
]}

Ying, Gui-shuang ^{[2
,10
,47
]}

Duros, Trang B. ^{[9
]}

Anh Nguyen ^{[9
]}

Maguire, Maureen G. ^{[10
]}

Brightwell-Arnold, Mary ^{[10
]}

Shaffer, James ^{[10
]}

Blanco, Maria ^{[10
]}

Brown, Trina ^{[10
]}

Helker, Christopher P. ^{[10
]}

Hutchinson, Amy ^{[11
]}

Young, Carrie ^{[11
]}

McCourt, Emily ^{[12
]}

Lynch, Anne ^{[12
]}

Cathcart, Jennifer ^{[12
]}

Cerda, Ashlee ^{[12
]}

Bonnell, Levi ^{[12
]}

Thevarajah, Tamara ^{[12
]}

Barry, Gerard P. ^{[13
]}

Fisher, Marilyn ^{[13
]}

Battaglia, Maria V. ^{[13
]}

Drach, Alexm. ^{[13
]}

Hughes, Kevin ^{[13
]}

Meyer, Andrew ^{[14
,45
]}

Gogal, Christina ^{[14
]}

Beitler, Cynthia ^{[14
]}

Centolanza, Lauri ^{[14
]}

Moyer, Keith T. ^{[14
]}

Sobotor, Mary ^{[14
]}

Shepard, Jennifer A. ^{[15
]}

Doherty, Megan ^{[15
]}

Reynolds, James D. ^{[16
]}

Connelly, Erin ^{[16
]}

Cheeseman, Edward ^{[17
]}

Shirer, Kinsey ^{[17
]}

Bradham, Carol ^{[17
]}

McAlpine, Allison ^{[17
]}

Sunthankar, Sudeep ^{[17
]}

Abbasian, Javaneh ^{[18
]}

Lim, Janet ^{[18
]}

机构：

[1] Childrens Hosp Philadelphia, Div Ophthalmol, 3401 Civ Ctr Blvd,Ophthalmol 9 MAIN, Philadelphia, PA 19104 USA

[2] Univ Penn, Scheie Eye Inst, Perelman Sch Med, Philadelphia, PA 19104 USA

[3] Univ Calif San Francisco, Dept Ophthalmol, San Francisco, CA USA

[4] Univ Iowa, Div Neonatol, Iowa City, IA USA

[5] Johns Hopkins Univ, Div Neonatol, Baltimore, MD USA

[6] Vanderbilt Univ, Dept Ophthalmol, 221 Kirkland Hall, Nashville, TN 37235 USA

[7] Johns Hopkins Univ, Dept Ophthalmol, Baltimore, MD USA

[8] Nationwide Childrens Hosp, Dept Ophthalmol, Columbus, OH USA

[9] Childrens Hosp Philadelphia, Off Study Chair, Philadelphia, PA 19104 USA

[10] Univ Penn, Perelman Sch Med, Data Coordinating Ctr, Philadelphia, PA 19104 USA

[11] Emory Univ, Sch Med, Childrens Healthcare Atlanta, Clin Ctr, Atlanta, GA 30322 USA

[12] Univ Colorado, Univ Colorado Hosp, Childrens Hosp Colorado, Denver, CO 80202 USA

[13] Albany Med Coll, Albany, NY USA

[14] Lehigh Valley Hosp, Allentown, PA USA

[15] Johns Hopkins Univ, Johns Hopkins Hosp, Baltimore, MD 21218 USA

[16] SUNY Buffalo, Women & Childrens Hosp Buffalo, Buffalo, NY USA

[17] Med Univ South Carolina, Columbia, SC USA

[18] Univ Illinois, Chicago, IL USA

[19] Cincinnati Childrens Hosp Med Ctr, Good Samaritan Hosp, Cincinnati, OH 45229 USA

[20] Univ Cincinnati, Med Ctr, Cincinnati, OH 45267 USA

[21] Nationwide Childrens Hosp, Riverside Methodist Hosp, Grant Med Ctr, Doctors Hosp, Columbus, OH USA

[22] Kapiolani Med Ctr Women & Children, Honolulu, HI USA

[23] Univ Texas Houston, Childrens Mem Hermann Hosp, Houston, TX USA

[24] Indiana Univ, Riley Hosp Children, Indiana Univ Hlth, Bloomington, IN 47405 USA

[25] Univ Iowa, Stead Family Childrens Hosp, Iowa City, IA 52242 USA

[26] Queens Univ, Kingston Hlth Sci Ctr, Kingston, ON, Canada

[27] Loma Linda Univ, Childrens Hosp, Loma Linda, CA 92350 USA

[28] Univ Louisville, Norton Childrens Hosp, Louisville, KY 40292 USA

[29] Univ Minnesota, Masonic Childrens Hosp, Minneapolis, MN 55455 USA

[30] Vanderbilt Eye Inst, Nashville, TN USA

[31] Vanderbilt Univ, Med Ctr, Monroe Carell Jr Childrens Hosp Vanderbilt, Nashville, TN USA

[32] Univ Oklahoma, Hlth Sci Ctr, Childrens Hosp, OU Med Ctr, Norman, OK 73019 USA

[33] Univ Nebraska, Nebraska Med, Lincoln, NE 68583 USA

[34] Hosp Univ Penn, Childrens Hosp Philadelphia, Penn Hosp, 3400 Spruce St, Philadelphia, PA 19104 USA

[35] Univ Pittsburgh, Childrens Hosp Pittsburgh, Magee Women Hosp, UPMC, Pittsburgh, PA 15213 USA

[36] Rhode Isl Hosp, Women & Infants Hosp Rhode Isl, Providence, RI 02903 USA

[37] St Louis Univ, Cardinal Glennon Childrens Hosp, St Louis, MO 63103 USA

[38] Univ Utah, Primary Childrens Hosp, Salt Lake City, UT 84112 USA

[39] Univ Utah Hosp, Salt Lake City, UT USA

[40] Univ Calif San Francisco, Benioff Childrens Hosp, San Francisco, CA 94143 USA

[41] Zuckerberg San Francisco Gen Hosp, San Francisco, CA USA

[42] Univ Washington, Seattle Childrens Hosp, Med Ctr, Seattle, WA 98195 USA

[43] Hosp Sick Children Sick Kids, Toronto, ON, Canada

[44] Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Los Angeles, CA USA

[45] Delaware Cty Mem Hosp, Crozer Chester Med Ctr, Drexel Hill, PA USA

[46] Nemours Alfred I duPont Hosp Children, Wilmington, DE USA

[47] Beth Israel Deaconess Med Ctr, Cost Effectiveness Component, Boston, MA 02215 USA

来源：

JAMA OPHTHALMOLOGY | 2020年 / 138卷 / 01期

基金：

美国国家卫生研究院;

关键词：

WEIGHT-GAIN; BIRTH-WEIGHT; COLORADO-RETINOPATHY; PRETERM INFANTS; FACTOR-I; PREDICTION; MODEL;

D O I：

10.1001/jamaophthalmol.2019.4517

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

This cohort study evaluates the generalizability of the Postnatal Growth and Retinopathy of Prematurity screening criteria in a new cohort of at-risk infants. Importance The first Postnatal Growth and Retinopathy of Prematurity Study (G-ROP-1) developed new screening criteria with 100% sensitivity for type 1 retinopathy of prematurity (ROP) and 30% reduction of infants requiring examinations in a retrospective development cohort of 7483 infants from 29 North American hospitals in 2006-2012. Infants meeting 1 or more of the following criteria undergo examinations: gestational age less than 28 weeks or birth weight less than 1051 g; weight gain less than 120 g during age 10 to 19 days, weight gain less than 180 g during age 20 to 29 days, or weight gain less than 170 g during age 30 to 39 days; or hydrocephalus. Objective To evaluate the generalizability of the G-ROP screening criteria in a new cohort of at-risk infants. Design, Setting, and Participants This prospective validation cohort study (G-ROP-2) was conducted at 41 hospitals in the United States and Canada (25 G-ROP-1 hospitals and 16 new hospitals) from September 8, 2015, to June 13, 2017, among 3981 premature infants at risk for ROP and with known ROP outcomes. Main Outcomes and Measures Sensitivity for Early Treatment for Retinopathy of Prematurity Study type 1 ROP and potential reduction in infants receiving examinations. Results Among the 3981 infants in the study (1878 girls and 2103 boys; median gestational age, 28 weeks [range, 22-35 weeks]; median birth weight, 1072 g [range, 350-4080 g]; 1966 white; 942 black; 321 Latino; 120 Asian; 22 Native Hawaian or Pacific Islander; and 25 American Indian or Alaskan Native), the G-ROP criteria correctly predicted 219 of 219 cases of type 1 ROP (sensitivity, 100%; 95% CI, 98.3%-100%), while reducing the number of infants undergoing examinations by 35.6% (n = 1418). In a combined G-ROP-1 and G-ROP-2 cohort of 11463 infants, the G-ROP criteria predicted 677 of 677 cases of type 1 ROP (sensitivity, 100%; 95% CI, 99.4%-100%), reducing the number of infants receiving examinations by 32.5% (n = 3730), while current criteria (birth weight <1501 g or gestational age <= 30 weeks 0 days) predicted 674 of 677 type 1 cases (sensitivity, 99.6%; 95% CI, 98.7%-99.8%). Conclusions and Relevance This study found that the G-ROP screening criteria were generalizable on validation and, if used clinically in the United States and Canada, could reduce the number of infants receiving examinations. The large G-ROP cohorts provide evidence-based screening criteria that have higher sensitivity and higher specificity (fewer infants receiving examinations) for type 1 ROP than currently recommended guidelines. Question Are the Postnatal Growth and Retinopathy of Prematurity modified screening criteria generalizable? Findings In a cohort study of 3981 premature infants, the Postnatal Growth and Retinopathy of Prematurity criteria correctly predicted type 1 retinopathy of prematurity in 219 of 219 infants, while reducing the number of infants receiving examinations by 35.6% if only infants meeting screening criteria received examinations. Meaning The modified screening criteria were validated and could be used clinically to reduce the number of infants receiving examinations while consistently identifying retinopathy of prematurity requiring treatment.

引用

页码：31 / 37

页数：7

共 27 条

[1] Prognosis and prognostic research: validating a prognostic model [J].

Altman, Douglas G. ;

Vergouwe, Yvonne ;

Royston, Patrick ;

Moons, Karel G. M. .

BMJ-BRITISH MEDICAL JOURNAL, 2009, 338 :1432-1435

[2] NeOProM: Neonatal Oxygenation Prospective Meta-analysis Collaboration study protocol [J].

Askie, Lisa M. ;

Brocklehurst, Peter ;

Darlow, Brian A. ;

Finer, Neil ;

Schmidt, Barbara ;

Tarnow-Mordi, William .

BMC PEDIATRICS, 2011, 11

[3] Development of Modified Screening Criteria for Retinopathy of Prematurity Primary Results From the Postnatal Growth and Retinopathy of Prematurity Study [J].

Binenbaum, Gil ;

Bell, Edward F. ;

Donohue, Pamela ;

Quinn, Graham ;

Shaffer, James ;

Tomlinson, Lauren A. ;

Ying, Gui-Shuang .

JAMA OPHTHALMOLOGY, 2018, 136 (09) :1034-1040

[4] Validation of the Children's Hospital of Philadelphia Retinopathy of Prematurity (CHOP ROP) Model [J].

Binenbaum, Gil ;

Ying, Gui-shuang ;

Tomlinson, Lauren A. .

JAMA OPHTHALMOLOGY, 2017, 135 (08) :871-877

[5] Postnatal Growth and Retinopathy of Prematurity Study: Rationale, Design, and Subject Characteristics [J].

Binenbaum, Gil ;

Tomlinson, Lauren A. .

OPHTHALMIC EPIDEMIOLOGY, 2017, 24 (01) :36-47

[6] The CHOP Postnatal Weight Gain, Birth Weight, and Gestational Age Retinopathy of Prematurity Risk Model [J].

Binenbaum, Gil ;

Ying, Gui-shuang ;

Quinn, Graham E. ;

Huang, Jiayan ;

Dreiseitl, Stephan ;

Antigua, Jules ;

Foroughi, Negar ;

Abbasi, Soraya .

ARCHIVES OF OPHTHALMOLOGY, 2012, 130 (12) :1560-1565

[7] Colorado retinopathy of prematurity model: a multi-institutional validation study [J].

Cao, Jennifer H. ;

Wagner, Brandie D. ;

Cerda, Ashlee ;

McCourt, Emily A. ;

Palestine, Alan ;

Enzenauer, Robert W. ;

Braverman, Rebecca S. ;

Wong, Ryan K. ;

Tsui, Irena ;

Gore, Charlotte ;

Robbins, Shira L. ;

Puente, Michael A., Jr. ;

Kauffman, Levi ;

Kong, Lingkun ;

Morrison, David G. ;

Lynch, Anne M. .

JOURNAL OF AAPOS, 2016, 20 (03) :220-225

[8] The Colorado-retinopathy of prematurity model (CO-ROP): postnatal weight gain screening algorithm [J].

Cao, Jennifer H. ;

Wagner, Brandie D. ;

McCourt, Emily A. ;

Cerda, Ashlee ;

Sillau, Stefan ;

Palestine, Alan ;

Enzenauer, Robert W. ;

Mets-Halgrimson, Rebecca B. ;

Paciuc-Beja, Miguel ;

Gralla, Jane ;

Braverman, Rebecca S. ;

Lynch, Anne .

JOURNAL OF AAPOS, 2016, 20 (01) :19-24

[9]

Zepeda-Romero LC, 2012, ARCH OPHTHALMOL-CHIC, V130, P720, DOI 10.1001/archophthalmol.2012.215

[10] A predictive score for retinopathy of prematurity in very low birth weight preterm infants [J].

Eckert, G. U. ;

Fortes Filho, J. B. ;

Maia, M. ;

Procianoy, R. S. .

EYE, 2012, 26 (03) :400-406

← 1 2 3 →