We consider a general two-component plasma of classical pointlike charges + e (e is say the elementary charge) and -Ze (valency Z = 1, 2,...), living on the surface of a sphere of radius R. The system is in thermal equilibrium at the inverse temperature beta, in the stability region against collapse of oppositely charged particle pairs beta e(2) < 2/Z. We study the effect of the system excess charge Qe on the finite-size expansion of the (dimensionless) grand potential beta Omega. By combining the stereographic projection of the sphere onto an infinite plane, the linear response theory and the planar results for the second moments of the species density correlation functions we show that for any beta e(2) < 2/Z the large-R expansion of the grand potential is of the form beta Omega similar to AV R-2 + [chi/6-beta(Qe)(2)/2] ln R, where AV is the non-universal coefficient of the volume (bulk) part and the Euler number of the sphere chi = 2. The same formula, containing also a non-universal surface term proportional to R, was obtained previously for the disc domain (chi = 1), in the case of the symmetric (Z = 1) two-component plasma at the collapse point beta e(2) = 2 and the jellium model (Z -> 0) of identical e-charges in a fixed neutralizing background charge density at any coupling beta e(2) being an even integer. Our result thus indicates that the prefactor to the logarithmic finite-size expansion does not depend on the composition of the Coulomb fluid and its non-universal part -beta(Qe)(2)/2 is independent of the geometry of the confining domain.