Efficacy of Adjuvant Gemcitabine-Cisplatin Chemotherapy: A Comparative Study between Locally Advanced Transitional Cell Carcinoma of the Bladder and Upper Urinary Tract

被引：6

作者：

Song, Yun Seob ^{[2
]}

Cho, Jin Seon ^{[3
]}

Cho, Kang Su

Doo, Seung Hwan

Chung, Byung Ha

Kim, Se Joong ^{[4
]}

Yang, Won Jae ^{[2
]}

Song, Ki Hak ^{[5
]}

Kim, Chun Il ^{[6
]}

Hong, Sung Joon ^{[1
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Urol, Seoul, South Korea

[2] Soonchunhyang Univ, Coll Med, Dept Urol, Seoul, South Korea

[3] Hallym Univ, Chunchon, South Korea

[4] Ajou Univ, Suwon 441749, South Korea

[5] Konyang Univ, Taejon, South Korea

[6] Keimyung Univ, Taegu, South Korea

来源：

UROLOGIA INTERNATIONALIS | 2010年 / 85卷 / 01期

关键词：

Transitional cell carcinoma; Chemotherapy; Bladder; Renal pelvis; Ureter; LONG-TERM-SURVIVAL; PLUS CISPLATIN; PHASE-II; RADICAL CYSTECTOMY; RANDOMIZED-TRIAL; CANCER; METHOTREXATE; VINBLASTINE; UROTHELIUM; DOXORUBICIN;

D O I：

10.1159/000296294

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To evaluate the comparative efficacy of adjuvant gemcitabine and cisplatin (GC) chemotherapy between patients with locally advanced transitional cell carcinoma (TCC) of the bladder and upper urinary tract. Patients and Methods: From 2001 to 2005, we retrospectively selected a total of 64 patients with locally advanced TCC of the bladder and upper urinary tract who received at least 3 cycles of adjuvant GC chemotherapy. We compared disease-free and overall survival between the 2 groups. Results: The recurrence rate was 30.3% in TCC of the bladder and 25.8% of the upper urinary tract (p = 0.633). Statistical analysis revealed that there was no significant difference in the disease-free or overall survival rate between TCC of the bladder and upper urinary tract treated with adjuvant GC chemotherapy. Conclusion: Under the circumstances of limited data about TCC of the upper urinary tract, this study may suggest that adjuvant GC chemotherapy in locally advanced TCC of the upper urinary tract is as effective as those of bladder. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：47 / 51

页数：5