Geometric formalism for DNA quadruplex folding

被引：191
作者：
da Silva, Mateus Webba [1 ]
机构：
[1] Univ Ulster, Sch Biomed Sci, CMB, Coleraine BT52 1SA, Londonderry, North Ireland
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2007年 / 13卷 / 35期
关键词：
DNA structures; glycosides; guanine;
D O I：
10.1002/chem.200701255
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Understanding the control of self-assembly and stereochemical properties of DNA higher order architectural folds is of fundamental importance in biology as well as biochemical technological applications. Guanine-rich DNA sequences can form tetrahelical architectures termed quadruplexes. A formalism is presented describing the interdependency of a set of structural descriptors as a geometric basis for folding of unimolecular quadruplex topologies. It represents a standard for interpretation of structural characteristics of quadruplexes, and is comprehensive in explicitly harmonizing the results of published literature with a unified language. The formalism is a fundamental step towards prediction of unimolecular quadruplex folding topologies from primary sequence.
引用
收藏
页码：9738 / 9745
页数：8
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