Gold-Catalyzed Synthesis of 3-Arylindoles via Annulation of Nitrosoarenes and Alkynes

被引：53

作者：

Murru, Siva ^{[1
]}

Gallo, August A. ^{[1
]}

Srivastava, Radhey S. ^{[1
]}

机构：

[1] Univ Louisiana Lafayette, Dept Chem, Lafayette, LA 70504 USA

来源：

ACS CATALYSIS | 2011年 / 1卷 / 01期

关键词：

annulation; 3-arylindole; alkynes; nitrosoarenes; gold catalysis; ONE-POT SYNTHESIS; ALLYLIC AMINATION; REDUCTIVE ANNULATION; EFFICIENT SYNTHESIS; INDOLE ALKALOIDS; DRUG LEADS; CONSTRUCTION; DERIVATIVES; CHEMISTRY; MECHANISM;

D O I：

10.1021/cs100024n

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We have successfully developed a Au-catalyzed annulation method to produce substituted 3-arylindoles from the reaction of nitrosoarenes with arylsubstituted acetylenes under reductive conditions using sodium borohydride. Terminal alkynes reacted better than non-terminal ones with various substituted nitrosoarenes to afford regioselective 3-substituted indoles. This method is simple and straightforward and can be applied successfully to the synthesis of highly substituted indoles.

引用

页码：29 / 31

页数：3

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