Roles of IFN-γ in effector mechanisms and pathogenicity of HSPs in mice and human infected with Toxoplasma gondii

被引：0

作者：

Yano, A ^{[1
]}

Mun, HS ^{[1
]}

Yang, TH ^{[1
]}

Hata, H ^{[1
]}

Kobayashi, M ^{[1
]}

Norose, K ^{[1
]}

Hayakawa, S ^{[1
]}

Tagawa, Y ^{[1
]}

Iwakura, Y ^{[1
]}

Nakazaki, S ^{[1
]}

Nakazaki, Y ^{[1
]}

Sekiya, S ^{[1
]}

Yamaura, A ^{[1
]}

Kubosawa, H ^{[1
]}

Yumoto, N ^{[1
]}

Aosai, F ^{[1
]}

机构：

[1] Chiba Univ, Sch Med, Dept Parasitol, Chiba 280, Japan

来源：

ICOPA IX - 9TH INTERNATIONAL CONGRESS OF PARASITOLOGY | 1998年

关键词：

D O I：

暂无

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Virulency of Toxoplasma gondii (T.gondii) is correlated with the antigen presenting ability of T.gondii-infected cells, and down-regulated MHC class II expression of T.gondii-infected cells was up-regulated by IFN-gamma. IFN-gamma or CTL specific for T.gondii-infected cells did not kill free T.gondii tachyzoites directly. When free tachyzoites and T.gondii in the host cells were exposed to acidic condition, destruction of the outer cell membrane and nuclear membrane of T.gondii and degradation of SAG1 gene were observed. HSP70 may play a role in antigen presentation and processing of T.gondii-infected P36 cells to CD4(+) CTL specific for T.gondii-infected cells. Increased HSP70 antibody levels in patients with toxoplasmosis and in patients with Vogt-Koyanagi-Harada disease (VKH) indicate that HSP70 may play an important role in the pathogenesis of toxoplasmosis and VKH.

引用

页码：457 / 466

页数：10

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