Roles of IFN-γ in effector mechanisms and pathogenicity of HSPs in mice and human infected with Toxoplasma gondii

被引：0

作者：

Yano, A ^{[1
]}

Mun, HS ^{[1
]}

Yang, TH ^{[1
]}

Hata, H ^{[1
]}

Kobayashi, M ^{[1
]}

Norose, K ^{[1
]}

Hayakawa, S ^{[1
]}

Tagawa, Y ^{[1
]}

Iwakura, Y ^{[1
]}

Nakazaki, S ^{[1
]}

Nakazaki, Y ^{[1
]}

Sekiya, S ^{[1
]}

Yamaura, A ^{[1
]}

Kubosawa, H ^{[1
]}

Yumoto, N ^{[1
]}

Aosai, F ^{[1
]}

机构：

[1] Chiba Univ, Sch Med, Dept Parasitol, Chiba 280, Japan

来源：

ICOPA IX - 9TH INTERNATIONAL CONGRESS OF PARASITOLOGY | 1998年

关键词：

D O I：

暂无

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Virulency of Toxoplasma gondii (T.gondii) is correlated with the antigen presenting ability of T.gondii-infected cells, and down-regulated MHC class II expression of T.gondii-infected cells was up-regulated by IFN-gamma. IFN-gamma or CTL specific for T.gondii-infected cells did not kill free T.gondii tachyzoites directly. When free tachyzoites and T.gondii in the host cells were exposed to acidic condition, destruction of the outer cell membrane and nuclear membrane of T.gondii and degradation of SAG1 gene were observed. HSP70 may play a role in antigen presentation and processing of T.gondii-infected P36 cells to CD4(+) CTL specific for T.gondii-infected cells. Increased HSP70 antibody levels in patients with toxoplasmosis and in patients with Vogt-Koyanagi-Harada disease (VKH) indicate that HSP70 may play an important role in the pathogenesis of toxoplasmosis and VKH.

引用

页码：457 / 466

页数：10

共 50 条

[31] REPRODUCTIVE FAILURE IN MICE CHRONICALLY INFECTED WITH TOXOPLASMA-GONDII
STAHL, W
KANEDA, Y
NOGUCHI, T
PARASITOLOGY RESEARCH, 1994, 80 (01): : 22 - 28
[32] Evaluation of the effects of sulfamethoxazole on Toxoplasma gondii loads and stage conversion in IFN-γ knockout mice using QC-PCR
Belal, US
Norose, K
Aosai, F
Mun, HS
Ahmed, AK
Chen, M
Mohamed, RM
Piao, LX
Iwakura, Y
Yano, A
MICROBIOLOGY AND IMMUNOLOGY, 2004, 48 (03) : 185 - 193
[33] THE EFFECT OF AZITHROMYCIN AND CLINDAMYCIN ON MICE INFECTED WITH TOXOPLASMA-GONDII
LOGAR, J
LIKAR, M
JOURNAL OF CHEMOTHERAPY, 1993, 5 : 160 - 161
[34] Risk Assessment of Etanercept in Mice Chronically Infected With Toxoplasma gondii
Yang, Jing
Wang, Luyao
Xu, Dongmei
Tang, Ding
Li, Senyang
Du, Fen
Wang, Lixia
Zhao, Junlong
Fang, Rui
FRONTIERS IN MICROBIOLOGY, 2018, 9
[35] BeWo trophoblasts are unable to control replication of Toxoplasma gondii, even in the presence of exogenous IFN-γ
Oliveira, J. G.
Silva, N. M.
Santos, A. A. D.
Souza, M. A.
Ferreira, G. L. S.
Mineo, J. R.
Ferro, E. A. V.
PLACENTA, 2006, 27 (6-7) : 691 - 698
[36] Regulation of IFN-γ production by B effector 1 cells:: Essential roles for T-bet and the IFN-γ receptor
Harris, DP
Goodrich, S
Gerth, AJ
Peng, SL
Lund, FE
JOURNAL OF IMMUNOLOGY, 2005, 174 (11) : 6781 - 6790
[37] The role of IFN-γ-mediated host immune responses in monitoring and the elimination of Toxoplasma gondii infection
Ihara, Fumiaki
Yamamoto, Masahiro
INTERNATIONAL IMMUNOLOGY, 2024, 36 (05) : 199 - 210
[38] Reduction of regulatory T cells during acute Toxoplasma gondii infection is caused by IFN-γ
Olguin, Jonadab
Fernandez, Jacquelina
Salinas, Nohemi
Terrazas, Luis
Saavedra, Rafael
JOURNAL OF IMMUNOLOGY, 2015, 194
[39] The role of IFN-γ and toll-like receptors in nephropathy induced by Toxoplasma gondii infection
Kudo, M
Aosai, F
Mun, HS
Norose, K
Akira, S
Iwakura, Y
Yano, A
MICROBIOLOGY AND IMMUNOLOGY, 2004, 48 (08) : 617 - 628
[40] Murine leukocytes stimulation by Toxoplasma gondii antigens induces high level of IFN-γ production
Fattahi-Bafghi A.
Mirzaei F.
Mirjalili A.
Arababadi M.K.
Faridnia R.
Fakhar M.
Kalani H.
Comparative Clinical Pathology, 2020, 29 (2) : 533 - 537

← 1 2 3 4 5 →