Tuning the release profile of ketoprofen from poly(L-lactic acid) suture using supercritical CO2 impregnation process

被引:22
作者
Champeau, Mathilde [1 ]
Coutinho, Isabela Trindade [1 ]
Thomassin, Jean-Michel [2 ]
Tassaing, Thierry [3 ]
Jerome, Christine [2 ]
机构
[1] Fed Univ ABC, Ctr Engn Modeling & Appl Social Sci, BR-09210580 Santo Andre, SP, Brazil
[2] Univ Liege, CERM, CESAM RU, Sart Tilman B6A, B-4000 Liege, Belgium
[3] Univ Bordeaux, CNRS, UMR 5255, Inst Sci Mol,Grp Spectroscopie Mol, 351 Cours Liberat, F-33405 Talence, France
基金
巴西圣保罗研究基金会;
关键词
Supercritical carbon dioxide; Impregnation; Controlled release systems; Fiber; Anti-inflammatory drug; Hydrolysis; CARBON-DIOXIDE; ASSISTED IMPREGNATION; SOLVENT IMPREGNATION; KINETIC RELEASE; DRUGS; SOLUBILITY; BEHAVIOR; SORPTION; FILMS; DEGRADATION;
D O I
10.1016/j.jddst.2019.101468
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Poly(c-lactic acid) (PLLA) fibers were impregnated with the anti-inflammatory drug ketoprofen by supercritical CO2 (scCO(2)) assisted impregnation process, to develop drug-eluting absorbable sutures. This work indicates the possibility to tune not only the drug loading but also the release profile of ketoprofen from PLLA by modifying the impregnation (temperature and pressure) and depressurization (temperature and rate) conditions. Different PLLA sutures that release ketoprofen during 3 days up to 3 months were obtained. The release was shown to be governed by two parameters: the degradation rate of PLLA, that increases with the drug impregnation, and the sutures free volume, that was created due to scCO(2) sorbed and was partially conserved during depressurization. The degradation rate and the tensile strength loss of the suture are accelerated by ketoprofen since it catalyzes PLLA acid hydrolysis.
引用
收藏
页数:10
相关论文
共 43 条
[1]  
Anderson J.M., 2013, BIOMATER SCI INTROD, VThird Edit, P503
[2]   Sorption and swelling of semicrystalline polymers in supercritical CO2 [J].
Bonavoglia, B ;
Storti, G ;
Morbidelli, M ;
Rajendran, A ;
Mazzotti, M .
JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS, 2006, 44 (11) :1531-1546
[3]   Effect of operational conditions on the supercritical carbon dioxide impregnation of anti-inflammatory and antibiotic drugs in rigid commercial intraocular lenses [J].
Bouledjouidja, A. ;
Masmoudi, Y. ;
Sergent, M. ;
Badens, E. .
JOURNAL OF SUPERCRITICAL FLUIDS, 2017, 130 :63-75
[4]   Supercritical solvent impregnation of ophthalmic drugs on chitosan derivatives [J].
Braga, Mara E. M. ;
Pato, Maria T. Vaz ;
Costa Silva, Helio S. R. ;
Ferreira, Elisabeth I. ;
Gil, Maria H. ;
Duarte, Catarina M. M. ;
de Sousa, Herminio C. .
JOURNAL OF SUPERCRITICAL FLUIDS, 2008, 44 (02) :245-257
[5]  
Brittain H.G., 2009, POLYMORPHISM PHARM S, V2nd, P436
[6]   Drug loading of polymer implants by supercritical CO2 assisted impregnation: A review [J].
Champeau, M. ;
Thomassin, J. -M. ;
Tassaing, T. ;
Jerome, C. .
JOURNAL OF CONTROLLED RELEASE, 2015, 209 :248-259
[7]   In situ investigation of supercritical CO2 assisted impregnation of drugs into a polymer by high pressure FTIR micro-spectroscopy [J].
Champeau, M. ;
Thomassin, J. -M. ;
Jerome, C. ;
Tassaing, T. .
ANALYST, 2015, 140 (03) :869-879
[8]   In situ FTIR micro-spectroscopy to investigate polymeric fibers under supercritical carbon dioxide: CO2 sorption and swelling measurements [J].
Champeau, M. ;
Thomassin, J. -M. ;
Jerome, C. ;
Tassaing, T. .
JOURNAL OF SUPERCRITICAL FLUIDS, 2014, 90 :44-52
[9]   Solubility and Speciation of Ketoprofen and Aspirin in Supercritical CO2 by Infrared Spectroscopy [J].
Champeau, Mathilde ;
Thomassin, Jean-Michel ;
Jerome, Christine ;
Tassaing, Thierry .
JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2016, 61 (02) :968-978
[10]   Drug Loading of Sutures by Supercritical CO2 Impregnation: Effect of Polymer/Drug Interactions and Thermal Transitions [J].
Champeau, Mathilde ;
Thomassin, Jean-Michel ;
Tassaing, Thierry ;
Jerome, Christine .
MACROMOLECULAR MATERIALS AND ENGINEERING, 2015, 300 (06) :596-610