CGF treatment of leg ulcers: a randomized controlled trial

被引：15

作者：

Amato, Bruno ^{[1
,2
]}

Farina, Michele Angelo ^{[3
]}

Campisi, Silvana ^{[4
]}

Ciliberti, Marino ^{[5
]}

Di Donna, Vincenzo ^{[6
]}

Florio, Anna ^{[7
]}

Grasso, Antonino ^{[8
]}

Miranda, Rosario ^{[9
]}

Pompeo, Francesco ^{[10
]}

Farina, Eleonora ^{[3
]}

Serra, Raffaele ^{[2
,11
]}

Cirocchi, Roberto ^{[12
]}

Calemma, Francesca ^{[1
]}

Rocca, Aldo ^{[1
]}

Compagna, Rita ^{[2
,7
]}

机构：

[1] Univ Federico II Naples, Dept Clin Med & Surg, Via S Pansini 5, I-80131 Naples, Italy

[2] Interuniv Ctr Phlebolymphol CIFL, Int Res & Educ Program Clin & Expt Biotechnol, Catanzaro, Italy

[3] Villa Del Sole Hosp, Vasc Surg Unit, I-81100 Caserta, Italy

[4] S Andrea Hosp, Transfus Immunohematol Serv, I-00192 Rome, Italy

[5] Ulcer Serv Program, Naples, Italy

[6] Med Ctr Regenerat Home, Foggia, Italy

[7] Univ Campania Luigi Vanvitelli, Dept Cardiothorac & Resp Sci, Naples, Italy

[8] Univ Catania, Vasc Surg Unit, Policlin Vittorio Emanuele, POG Rodolico, Catania, Italy

[9] Angiol Serv ASL NA 3 Sud, I-80035 Naples, Italy

[10] Neurol Mediterranean Inst Neuromed, Vasc Surg Unit, I-86077 Pozzilli, Isernia, Italy

[11] Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, Catanzaro, Italy

[12] S Maria Hosp, Div Week Surg, Dept Surg & Biomed Sci, Terni, Italy

来源：

OPEN MEDICINE | 2019年 / 14卷 / 01期

关键词：

Concentrated Growth Factors; CGF; Pladet Rich Plasma; PRP; Mixed ulcers; Vascular ulcers; Leg ulcers; PLATELET-RICH PLASMA; GROWTH-FACTOR; CELLS; PRF;

D O I：

10.1515/med-2019-0113

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Concentrated Growth Factors (CGF) is a concentration of second generation autologous growth factors compared to platelet rich plasma (PRP) and represents a multifactorial stimulation system that can be used for the management and treatment of chronic skin ulcers. Aim: The aim of this work is to evaluate the additional benefits of the CGF compared to the standard of dressing and its effects on the dynamics of the healing process. Methods: Autologous CGFs were obtained from 100 patients with chronic mixed ulcers (venous ulcers in patients with II stage claudication) of the lower limbs in a multicentric controlled randomized study. Results: The results showed a significant advantage in the use of CGF in association with cleansing and selective compression in the healing time and stabilization of mixed ulcers of the lower extremities. Conclusions: These results support the CGF's clinical use for improving clinical outcomes in mixed ulcers of the legs.

引用

页码：959 / 967

页数：9

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