Review of the implications of dietary tryptophan intake in patients with irritable bowel syndrome and psychiatric disorders

被引:28
作者
Agazzi, A
De Ponti, F
De Giorgio, R
Candura, SM
Anselmi, L
Cervio, E
Di Nucci, A
Tonini, M
机构
[1] Univ Pavia, Dept Pharmacol & Physiol Sci, I-27100 Pavia, Italy
[2] Univ Bologna, Dept Pharmacol, Bologna, Italy
[3] Univ Bologna, Dept Internal Med & Gastroenterol, Bologna, Italy
[4] Univ Pavia, Dept Prevent Occupat & Community Med, I-27100 Pavia, Italy
关键词
irritable bowel syndrome; psychiatric disorders; tryptophan;
D O I
10.1016/S1590-8658(03)00277-9
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
In this review, we address the possible role of the essential amino acid L-tryptophan or its metabolic derivative 5-hydroxytryptophan in the modulation. of serotonin (5-hydroxytryptamine) synthesis and thereby in affecting the pathophysiology of central and peripheral nervous system disorders, including depression and irritable bowel syndrome. L-Tryptophan may represent a link between apparently disparate functional disorders and is of interest for general gastroenterologists, neurogastroenterologists, and neurologists. On the basis of estimates showing that approximately 20% of patients with functional bowel disorders seeking care in referral centres have psychiatric comorbidity, we attempt to provide a conceptual framework for defining the possible role of L-tryptophan in this population. (C) 2003 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:590 / 595
页数:6
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