Synthesis of imidazo[1,2-a]pyridines: a decade update

被引：576

作者：

Bagdi, Avik Kumar ^{[1
]}

Santra, Sougata ^{[1
]}

Monir, Kamarul ^{[1
]}

Hajra, Alakananda ^{[1
]}

机构：

[1] Visva Bharati Cent Univ, Dept Chem, Santini Ketan 731235, W Bengal, India

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 09期

关键词：

ONE-POT SYNTHESIS; INTRAMOLECULAR PROTON-TRANSFER; 3-COMPONENT REACTION; MULTICOMPONENT REACTION; FACILE SYNTHESIS; 2-AMINOPYRIDINES; DERIVATIVES; CYCLIZATION; CATALYST; ACCESS;

D O I：

10.1039/c4cc08495k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Imidazopyridine is one of the important fused bicyclic 5-6 heterocycles and it is recognized as a "drug prejudice" scaffold due to its wide range of applications in medicinal chemistry. This moiety is also useful in material science because of its structural character. Synthesis of this moiety from the easily available chemicals is desirable due to its tremendous use in the various branches of chemistry. Here we report a review on the synthesis of this scaffold employing different strategies such as condensation, multicomponent reactions, oxidative coupling, tandem reactions, aminooxygenation, and hydroamination reactions.

引用

页码：1555 / 1575

页数：21

共 92 条

[1]

Abignente E, 1991, ACTUAL CHIM TH R, V18, P193

[2] An efficient synthesis of 3-amino-2-arylimidazo[1,2-a]pyridines [J].

Adib, Mehdi ;

Sheibani, Esmail ;

Zhu, Long-Guan ;

Mirzaei, Peiman .

TETRAHEDRON LETTERS, 2008, 49 (34) :5108-5110

[3] Catalyst-free three-component reaction between 2-aminopyridines (or 2-aminothiazoles), aldehydes, and isocyanides in water [J].

Adib, Mehdi ;

Mahdavi, Mohammad ;

Noghani, Mahsa Alizadeh ;

Mirzaei, Peiman .

TETRAHEDRON LETTERS, 2007, 48 (41) :7263-7265

[4] One-pot synthesis of imidazo[1,2-a]pyridines from benzyl halides or benzyl tosylates, 2-aminopyridines and isocyanides [J].

Adib, Mehdi ;

Sheikhi, Ehsan ;

Rezaei, Narjes .

TETRAHEDRON LETTERS, 2011, 52 (25) :3191-3194

[5] DERIVATIVES OF IMIDAZOLE .I. SYNTHESIS AND REACTIONS OF IMIDAZO[1,2-A]PYRIDIENES WITH ANALGESIC ANTIINFLAMMATORY ANTIPYRETIC AND ANTICONVULSANT ACTIVITY [J].

ALMIRANTE, L ;

POLO, L ;

MUGNAINI, A ;

PROVINCIALI, E ;

RUGARLI, P ;

BIANCOTTI, A ;

GAMBA, A ;

MURMANN, W .

JOURNAL OF MEDICINAL CHEMISTRY, 1965, 8 (03) :305-+

[6] BENZIMIDAZOLE CONDENSED RING-SYSTEM .9. POTENTIAL ANTINEOPLASTICS - NEW SYNTHESIS OF SOME PYRIDO[1,2-A]BENZIMIDAZOLES AND RELATED DERIVATIVES [J].

BADAWEY, E ;

KAPPE, T .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1995, 30 (04) :327-332

[7] Copper-Catalyzed Synthesis of Imidazo[1,2-a]pyridines through Tandem Imine Formation-Oxidative Cyclization under Ambient Air: One-Step Synthesis of Zolimidine on a Gram-Scale [J].

Bagdi, Avik Kumar ;

Rahman, Matiur ;

Santra, Sougata ;

Majee, Adinath ;

Hajra, Alakananda .

ADVANCED SYNTHESIS & CATALYSIS, 2013, 355 (09) :1741-1747

[8]

Bartholini G., 1993, MONOGR SER, V8, P1

[9] Cu-Mn spinel oxide catalyzed synthesis of imidazo[1,2-a]pyridines through domino three-component coupling and 5-exo-dig cyclization in water [J].

Bharate, Jaideep B. ;

Guru, Santosh K. ;

Jain, Shreyans K. ;

Meena, Samdarshi ;

Singh, Parvinder Pal ;

Bhushan, Shashi ;

Singh, Baldev ;

Bharate, Sandip B. ;

Vishwakarma, Ram A. .

RSC ADVANCES, 2013, 3 (43) :20869-20876

[10]

Boerner RJ, 1997, PSYCHOPHARMAKOTHERAP, V4, P145

← 1 2 3 4 5 6 7 8 9 10 →