Heterostructures of MOFs and Nanorods for Multimodal Imaging

被引：70
作者：
Zhang, Hongyu [1 ,2 ]
Hao, Changlong [1 ,2 ]
Qu, Aihua [1 ,2 ]
Sun, Maozhong [1 ,2 ]
Xu, Liguang [1 ,2 ]
Xu, Chuanlai [1 ,2 ]
Kuang, Hua [1 ,2 ]
机构：
[1] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China
[2] Jiangnan Univ, Sch Food Sci & Technol, Int Joint Res Lab Biointerface & Biodetect, Wuxi 214122, Jiangsu, Peoples R China
来源：
ADVANCED FUNCTIONAL MATERIALS | 2018年 / 28卷 / 48期
基金：
中国国家自然科学基金;
关键词：
chemotherapy; heterodimer; metal-organic frameworks; multimodal imaging; photothermal; METAL-ORGANIC FRAMEWORKS; ONE-POT SYNTHESIS; NANOPARTICLES; RELEASE; DOTS;
D O I：
10.1002/adfm.201805320
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Multifunctional heterostructures fabricated by assembling individual components are identified as a potential theranostic tool in biological fields, representing a strategy of great significance. Herein, heterodimers of the zeolitic imidazolate framework (ZIF)-8 and gold nanorods (Au NRs) are designed and synthesized for collaborative photothermal treatment and chemotherapy triggered by near-infrared (NIR) light. Furthermore, Ag2S, Ag2Se, upconversion fluorescent nanoparticles, and doxorubicin hydrochloride loaded into the ZIF-8 are released after intravenous injection. This release is attributed to the pH-responsive system, which simultaneously enabled computed tomography, photoacoustic, and NIR fluorescence imaging for tumors. Under NIR irradiation using an 808 nm laser, the tumor can be completely eliminated in vivo through multimodal imaging-guided chemophotothermal treatment. Overall, the present study makes several noteworthy contributions to the efficient diagnosis and treatment of cancer using the metal-organic framework-assisted heterodimer as a versatile nanoplatform.
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页数：9
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