MR imaging assessment of changes in renal function with renal artery stent placement in swine

被引:6
|
作者
Park, Jonathan K.
Rhee, Thomas K.
Cashen, Ty A.
Shin, Wanyong
Resnick, Scott A.
Gehl, James A.
Schirf, Brian E.
Wang, Dingxin
Larson, Andrew C.
Carroll, Timothy J.
Omary, Reed A.
机构
[1] Northwestern Univ, Feinberg Sch Med, Dept Radiol, Chicago, IL 60611 USA
[2] Northwestern Univ, Feinberg Sch Med, Dept Biomed Engn, Chicago, IL 60611 USA
关键词
D O I
10.1016/j.jvir.2007.08.002
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
PURPOSE: To prospectively test the hypothesis that magnetic resonance (MR) imaging can detect changes in renal function at the time of renal artery stent placement in a swine model of renal artery stenosis (RAS). MATERIALS AND METHODS: In this animal care and use committee-approved study, hemodynamically significant (>50%) RAS was surgically induced in six pigs. MR imaging was employed for assessment of the anatomic and physiologic changes induced by fluoroscopically guided stent placement. With MR imaging, we assessed changes in renal blood flow (RBF), extraction fraction (EF), and single-kidney glomerular filtration rate (skGFR) during the procedure. Arterial diameter stenosis before and after stent placement was assessed with x-ray digital subtraction angiography (DSA). Mean changes in functional and anatomic parameters were compared with the Wilcoxon matched-pairs test, with an a level of 0.05. RESULTS: There was no significant change in mean RBF after stent deployment (P =.44). Mean EF increased from 0.19 +/- 0.08 before stent placement to 0.31 +/- 0.17 after stent placement (P =.16). Mean skGFR measurements were 25 mL/min +/- 16 before stent placement and 41 mL/min +/- 28 after stent placement (P <.05). According to x-ray DSA measurements, mean stenosis measurements were 60% +/- 12% before stent placement and 24% +/- 16% after stent placement (P <.02). CONCLUSIONS: In swine, MR imaging can detect immediate changes in renal function after radiographically guided stent placement for unilateral RAS. This functional MR technique may have applications in the setting of hybrid MR/x-ray DSA procedure suites.
引用
收藏
页码:1409 / 1416
页数:8
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