A convenient synthesis of 4-aryl-1,8-naphthyridin-2(1H)-ones by the Suzuki coupling

被引：17

作者：

Ban, H ^{[1
]}

Muraoka, M ^{[1
]}

Ohashi, N ^{[1
]}

机构：

[1] Sumitomo Pharmaceut Co Ltd, Div Res, Konohana Ku, Osaka 5540022, Japan

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 32期

关键词：

cyclization; Suzuki coupling; 4-aryl-1,8-naphthyridine-2-ones;

D O I：

10.1016/S0040-4039(03)01517-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-Halo-1,8-naphthyridin-2(1H)-ones readily available from 2-chloronicotinic acid were subjected to the Suzuki coupling reaction with arylboronic acids to give a diversity of 4-aryl-1,8-naphthyridin-2(1H)-ones. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：6021 / 6023

页数：3

共 23 条

[1] SYNTHESIS OF NEW 1H,3H-PYRIDO[2,3-D]PYRIMIDINE-2,4-DIONES [J].

BRUNEL, S ;

MONTGINOUL, C ;

TORREILLES, E ;

GIRAL, L .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1980, 17 (02) :235-240

[2] 4-HYDROXY-3-NITRO-2-QUINOLONES AND RELATED COMPOUNDS AS INHIBITORS OF ALLERGIC REACTIONS [J].

BUCKLE, DR ;

CANTELLO, BCC ;

SMITH, H ;

SPICER, BA .

JOURNAL OF MEDICINAL CHEMISTRY, 1975, 18 (07) :726-732

[3]

CHENG CC, 1982, ORG REACTIONS, V28, P37

[4]

DAVIS HL, 1985, EUR J MED CHEM, V20, P381

[5] NITRILES IN ORGANIC-SYNTHESIS - SYNTHESIS OF AROMATIC-AMINES, AMINOPYRIDINES, PYRIDO[2,3-B]PYRIDINE AND PYRIDO[2,3-D]PYRIMIDINE DERIVATIVES [J].

ELTAWEEL, FM .

JOURNAL FUR PRAKTISCHE CHEMIE, 1990, 332 (05) :762-766

[6] Palladium-catalyzed cross-coupling reactions for the synthesis of 6,8-disubstituted 1,7-naphthyridines:: A novel class of potent and selective phosphodiesterase type 4D inhibitors [J].

Hersperger, R ;

Bray-French, K ;

Mazzoni, L ;

Müller, T .

JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (04) :675-682

[7] BISUBSTRATE REACTION TEMPLATES - EXAMINATION OF THE CONSEQUENCES OF IDENTICAL VERSUS DIFFERENT BINDING-SITES [J].

KELLY, TR ;

BRIDGER, GJ ;

ZHAO, C .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (22) :8024-8034

[8] STUDIES ON THE SYNTHESES OF 2(1H)-PYRIDONE DERIVATIVES .3. SYNTHESIS OF 6-AMINO-2(1H)-PYRIDONES AND THEIR CYCLIZATION [J].

KUBO, K ;

ITO, N ;

ISOMURA, Y ;

SOZU, I ;

HOMMA, H ;

MURAKAMI, M .

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1979, 99 (08) :788-793

[9] A NOVEL SYNTHESIS AND POTENT ANTIINFLAMMATORY ACTIVITY OF 4-HYDROXY-2(1H)-OXO-1-PHENYL-1,8-NAPHTHYRIDINE-3-CARBOXAMIDES [J].

KURODA, T ;

SUZUKI, F ;

TAMURA, T ;

OHMORI, K ;

HOSOE, H .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (06) :1130-1136

[10] A FACILE AND NOVEL SYNTHESIS OF 5-PHENYLIMIDAZO[4,5-C][1,8]NAPHTHYRIDIN-4(5H)-ONES [J].

KURODA, T ;

SUZUKI, F .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1991, 28 (08) :2029-2034

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