Shock wave therapy for femoral head necrosis-Pressure measurements inside the femoral head

被引：43

作者：

Hausdorf, J. ^{[1
]}

Lutz, A. ^{[2
]}

Mayer-Wagner, S. ^{[1
]}

Birkenmaier, C. ^{[1
]}

Jansson, V. ^{[1
]}

Maier, M. ^{[1
]}

机构：

[1] Univ Munich, Dept Orthopaed, D-81377 Munich, Germany

[2] Dornier MedTech GmbH, D-82234 Wessling, Germany

来源：

JOURNAL OF BIOMECHANICS | 2010年 / 43卷 / 11期

关键词：

Femoral head necrosis; Shock wave; Pressure measurement; Bone; IN-VIVO; SEGMENTAL DEFECT; BONE; EXPRESSION; VEGF; OSTEONECROSIS; RECRUITMENT; ISCHEMIA; PULSES; CELLS;

D O I：

10.1016/j.jbiomech.2010.04.009

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

There is a persisting need for effective therapies of femoral head necrosis, a common bone disease. Promising clinical results have been stated for the treatment with extracorporeal shock waves (ESW). However, the effective remaining pressure in the target region inside the femoral head has never been determined. Aim of this study was to investigate whether ESW are able to propagate through bone without an excessive loss of pressure. The remaining ESW pressure generated by an electromagnetic device after passing a certain intraosseous distance within the femoral head was measured. Standardized holes were drilled in porcine femora and the absorption in relation to reference measurements in degassed water was determined. The results showed continuous attenuation of shock waves in bone. After a clinical relevant intraosseous distance of 10 mm an ESW pressure of 50% remained. In conclusion, ESW have the potential to reach necrotic regions with therapeutic pressure levels and to effectively treat femoral head necrosis. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2065 / 2069

页数：5

共 26 条

[1] Low-energy shock wave for enhancing recruitment of endothelial progenitor cells - A new modality to increase efficacy of cell therapy in chronic hind limb ischemia [J].