Impact of high-fat diet on liver genes expression profiles in mice model of nonalcoholic fatty liver disease

被引:43
作者
Wang, Chunhua [1 ,2 ]
Tao, Qimeng [1 ,3 ]
Wang, Xinghe [1 ]
Wang, Xiurong [3 ]
Zhang, Xiuying [1 ]
机构
[1] Northeast Agr Univ, Coll Vet Med, Dept Vet Basic Sci, Harbin 150030, Heilongjiang, Peoples R China
[2] Mudanjiang Normal Univ, Fac Life Sci & Technol, Mudanjiang 157012, Peoples R China
[3] Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin 150001, Peoples R China
关键词
Nonalcoholic fatty liver disease; Liver gene expression; Drug metabolizing enzymes; Cytochrome P450; ACTIVATED RECEPTOR-ALPHA; HEPATIC STEATOSIS; PPAR-ALPHA; METABOLISM; FIBROBLAST-GROWTH-FACTOR-21; CYTOCHROME-P450; PATHOGENESIS; OXIDATION; PATHOLOGY; INSULIN;
D O I
10.1016/j.etap.2016.05.014
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Evidences have shown that NAFLD influences expression of some drug metabolic enzyme genes. This study aims to investigate the role of HFD-induced NAFLD in regulating the transcription of genes, particularly the drug metabolizing genes variation. Transcriptome analysis demonstrated that HFD feeding caused the 150 genes expression to change, most genes associated with lipid metabolism, inflammatory, oxidative stress and oxidoreductase activity up-regulated, whereas most genes involved in nucleic acid metabolism repressed. The genes involved in drug metabolism had 16 down-regulated and 21 up regulated in NAFLD. The over-4-fold change genes included the down-regulation of Cyp8b1, Cyp7a1, Sult3a1, Sult1e1, Cypl7al, Cyp3a41a, Gstt3, Cyp51, Cyp2c54 and Cyp4f14, and the up-regulation of Asns, Pastl, Cyp2c55, Gstm2, Cyp2e1 and Gsta alpha l. In conclusion, significant alterations in the expression of drug metabolizing enzymes may affect the clearance of therapeutic drugs, with the potential to result in adverse drug reactions or drug toxicity in nonalcoholic fatty liver disease. (c) 2016 Published by Elsevier B.V.
引用
收藏
页码:52 / 62
页数:11
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