Antimicrobial Susceptibility Patterns of Clinical Isolates of Gram-Negative Bacteria Obtained from Intensive Care Units in a Tertiary Hospital in Beijing, China

被引：7

作者：

Meng, Xianghong ^{[1
]}

Dong, Mei ^{[1
]}

Wang, Di ^{[1
]}

He, Jufang ^{[1
]}

Yang, Caie ^{[1
]}

Zhu, Lei ^{[1
]}

Sun, Minxia ^{[1
]}

机构：

[1] Chinese PLA 309 Hosp, Dept Clin Lab, Beijing 100091, Peoples R China

来源：

JOURNAL OF CHEMOTHERAPY | 2011年 / 23卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Gram-negative bacteria; ICU; antimicrobial resistance; MDR; TIGECYCLINE EVALUATION; SURVEILLANCE TRIAL; NORTH-AMERICA; RESISTANCE; ENTEROBACTERIACEAE; PREVALENCE; ICU;

D O I：

10.1179/joc.2011.23.4.207

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this study we investigated the prevalence of antimicrobial resistance in clinical isolates of Gram-negative bacteria obtained from intensive care units (ICUs) in the People's Liberation Army (PLA) 309 Hospital located in Beijing, China. Between 2007 and 2010, a total of 1949 isolates of Gram-negative bacteria were collected and tested using an antibiotic susceptibility assay. A marked decrease was observed in the susceptibility of Acinetobacter baumannii to imipenem and amikacin as compared to that described in a previous report in China. Similar results were obtained for Pseudomonas aeruginosa. However, imipenem and amikacin showed strong activity against Escherichia coli and Klebsiella pneumoniae. Overall, the high rates of antimicrobial resistance against ICU pathogens in our hospital indicated a critical condition in Beijing, China. Development of a national control and monitoring system by the government may be an ideal method to solve the present problem of managing infections due to Gram-negative bacterial pathogens.

引用

页码：207 / 210

页数：4

共 14 条

[1] Three cefotaximases, CTX-M-9, CTX-M-13, and CTX-M-14, among Enterobacteriaceae in the People's Republic of China [J].

Chanawong, A ;

M'Zali, FH ;

Heritage, J ;

Xiong, JH ;

Hawkey, PM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (03) :630-637

[2]

Clinical and Laboratory Standards Institute (CLSI), 2010, M100S20U CLSI

[3] Update on Antimicrobial Susceptibility Rates Among Gram-Negative and Gram-Positive Organisms in the United States: Results from the Tigecycline Evaluation and Surveillance Trial (TEST) 2005 to 2007 [J].

Dowzicky, Michael J. ;

Park, Chocing H. .

CLINICAL THERAPEUTICS, 2008, 30 (11) :2040-2050

[4] Increasing prevalence of antimicrobial resistance in intensive care units [J].

Fridkin, SK .

CRITICAL CARE MEDICINE, 2001, 29 (04) :N64-N68

[5]

Jung S, 2010, ANN CLIN LAB SCI, V40, P167

[6] Antimicrobial Susceptibility Among Bacterial Isolates from ICU and Non-ICU Settings and Different Age Groups: Results from the Tigecycline Evaluation and Surveillance Trial in North America [J].

Low, D. E. ;

Markovic, M. J. ;

Dowzicky, M. J. .

JOURNAL OF CHEMOTHERAPY, 2009, 21 (01) :16-23

[7] Antimicrobial susceptibility pattern comparisons among intensive care unit and general ward Gram-negative isolates from the Meropenem Yearly Susceptibility Test Information Collection Program (USA) [J].

Rhomberg, Paul R. ;

Fritsche, Thomas R. ;

Sader, Helio S. ;

Jones, Ronald N. .

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2006, 56 (01) :57-62

[8] Managing infection in the critical care unit: how can infection control make the ICU safe? [J].

Shulman, L ;

Ost, D .

CRITICAL CARE CLINICS, 2005, 21 (01) :111-+

[9] Assessment of pathogen occurrences and resistance profiles among infected patients in the intensive care unit: report from the SENTRY Antimicrobial Surveillance Program (North America, 2001) [J].

Streit, JM ;

Jones, RN ;

Sader, HS ;

Fritsche, TR .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2004, 24 (02) :111-118

[10] Clinical isolates of Enterobacteriaceae producing extended-spectrum β-lactamases:: Prevalence of CTX-M-3 at a hospital in China [J].

Wang, H ;

Kelkar, S ;

Wu, WY ;

Chen, MJ ;

Quinn, JP .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (02) :790-793

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