Inhibition of PRAME expression causes cell cycle arrest and apoptosis in leukemic cells

被引：37
|
作者：
Tanaka, Norina [1 ]
Wang, Yan-Hua [1 ]
Shiseki, Masayuki [1 ]
Takanashi, Minoko [2 ]
Motoji, Toshiko [1 ]
机构：
[1] Tokyo Womens Med Univ, Dept Hematol, Tokyo, Japan
[2] Japanese Red Cross Tokyo Metropolitan Blood Ctr, Blood Preparat Dept, Tokyo, Japan
来源：
LEUKEMIA RESEARCH | 2011年 / 35卷 / 09期
关键词：
PRAME; siRNA; Acute leukemia; Cell cycle; Apoptosis; Differentiation; CHRONIC MYELOID-LEUKEMIA; BREAST-CANCER; ANTIGEN; MELANOMA; GENE; IDENTIFICATION; RECEPTOR;
D O I：
10.1016/j.leukres.2011.04.005
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The preferentially expressed antigen of melanoma (PRAME) is known as a tumor-associated antigen, but its function in leukemia remains unclear. We investigated the function with small interfering RNA (siRNA)-induced knockdown of PRAME in a K562 cell line. After PRAME siRNA transfection, proliferation was suppressed and cell cycle analysis showed G(0)/G(1) arrest, followed by apoptosis. PRAME siRNA-treated cells also showed changes in the genes affecting erythroid differentiation. We examined the PRAME expression levels and the S phase population of 32 acute leukemia patients at the time of diagnosis and relapse. An increase of the S phase population was accompanied by an increase of PRAME expression at relapse. Our results suggest that PRAME plays an important role in disease progression in acute leukemia. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1219 / 1225
页数：7
相关论文
共 50 条
  • [31] Inhibition of ultraviolet B (UVB) induced apoptosis in A431 cells by mimosine is not dependent on cell cycle arrest
    Cliche, DO
    Girouard, S
    Bissonnette, N
    Hunting, DJ
    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2002, 80 (07) : 650 - 653
  • [32] Iberin induces cell cycle arrest and apoptosis in human neuroblastoma cells
    Jadhav, Unmesh
    Ezhilarasan, Ravesanker
    Vaughn, Steven F.
    Berhow, Mark A.
    Mohanam, Sanjeeva
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2007, 19 (03) : 353 - 361
  • [33] Disulfiram/copper causes ROS levels alteration, cell cycle inhibition, and apoptosis in acute myeloid leukaemia cell lines with modulation in the expression of related genes
    Hassani, Saeed
    Ghaffari, Parisa
    Chahardouli, Bahram
    Alimoghaddam, Kamran
    Ghavamzadeh, Ardeshir
    Alizadeh, Shaban
    Ghaffari, Seyed H.
    BIOMEDICINE & PHARMACOTHERAPY, 2018, 99 : 561 - 569
  • [34] Inhibition of Id proteins by a peptide aptamer induces cell-cycle arrest and apoptosis in ovarian cancer cells
    Mern, D. S.
    Hasskarl, J.
    Burwinkel, B.
    BRITISH JOURNAL OF CANCER, 2010, 103 (08) : 1237 - 1244
  • [35] Inhibition of Period Gene Expression Causes Repression of Cell Cycle Progression and Cell Growth in the Bombyx mori Cells
    Qiu, Jian-Feng
    Li, Xue
    Cui, Wen-Zhao
    Liu, Xiao-Fei
    Tao, Hui
    Yang, Kun
    Dai, Tai-Ming
    Sima, Yang-Hu
    Xu, Shi-Qing
    FRONTIERS IN PHYSIOLOGY, 2019, 10
  • [36] Centaurea bruguieranainhibits cell proliferation, causes cell cycle arrest, and induces apoptosis in human MCF-7 breast carcinoma cells
    Nasr, Fahd A.
    Shahat, Abdelaaty A.
    Alqahtani, Ali S.
    Ahmed, Mohammad Z.
    Qamar, Wajhul
    Al-Mishari, Abdullah A.
    Almoqbil, Abdulaziz N.
    MOLECULAR BIOLOGY REPORTS, 2020, 47 (08) : 6043 - 6051
  • [37] Anticancer effects of bishydroxycoumarin are mediated through apoptosis induction, cell migration inhibition and cell cycle arrest in human glioma cells
    Zhang, Cheng-Gang
    Huang, Jing-Chun
    Liu, Tao
    Li, Xiang-Ying
    JOURNAL OF BUON, 2015, 20 (06): : 1592 - 1600
  • [38] Leptin stimulation of cell cycle and inhibition of apoptosis gene and protein expression in OVCAR-3 ovarian cancer cells
    Ptak, Anna
    Kolaczkowska, Elzbieta
    Gregoraszczuk, Ewa L.
    ENDOCRINE, 2013, 43 (02) : 394 - 403
  • [39] The expression of PTEN in HEK293 cells induces apoptosis and cell cycle arrest
    Zhang, LN
    Yu, Q
    Zha, XL
    PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2003, 30 (02) : 204 - 208
  • [40] Cell cycle arrest and apoptosis are early events in radiosensitization of EWS::FLI1+ Ewing sarcoma cells by Mithramycin A
    Lin, Mei Yun
    Damron, Timothy A.
    Horton, Jason A.
    INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2023, 99 (10) : 1570 - 1583
12345