Synthesis of fused bicyclic glutarimides

被引：10

作者：

Chang, MY ^{[1
]}

Chen, CY

Chen, ST

Chang, NC

机构：

[1] Natl Univ Kaohsiung, Dept Appl Chem, Kaohsiung 811, Taiwan

[2] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 804, Taiwan

[3] Acad Sinica, Inst Biol Chem, Taipei 115, Taiwan

来源：

TETRAHEDRON | 2003年 / 59卷 / 38期

关键词：

bicyclic glutarimides; stepwise [3+3] annulation; intramolecular alkylation; oxidative cyclization or ring-closing metathesis;

D O I：

10.1016/S0040-4020(03)01198-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe an efficient route towards the synthesis of fused bicyclic glutarimides using facile [3+3] reaction of alpha-sulfonylacetamides with different alpha,beta-unsaturated esters as the key step. Intramolecular cyclization of 4-substituted 3-sulfonylglutarimide to form 5,6-, 6,6- or 6,7-fused bicyclic glutarimides was accomplished via alkylation, oxidative cyclization or ring-closing metathesis in modest yield. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：7547 / 7553

页数：7

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