Theoretical analysis of a transdermal ferromagnetic implant for retention of magnetic drug carrier particles

被引：68
作者：
Avilés, MO
Ebner, AD
Chen, HT
Rosengart, AJ
Kaminski, MD
Ritter, JA [1 ]
机构：
[1] Univ S Carolina, Dept Chem Engn, Columbia, SC 29208 USA
[2] Univ Chicago, Pritzker Sch Med, Dept Neurol, Chicago, IL 60637 USA
[3] Univ Chicago, Pritzker Sch Med, Dept Surg Neurosurg, Chicago, IL 60637 USA
[4] Argonne Natl Lab, Div Chem Engn, Argonne, IL 60439 USA
来源：
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2005年 / 293卷 / 01期
关键词：
magnetic drug targeting; drug delivery; magnetic wire; high gradient magnetic separation; circulatory system; magnetic implant; simulation; blood flow; model;
D O I：
10.1016/j.jmmm.2005.01.089
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
The use of a ferromagnetic wire implant placed near an artery to assist the collection of magnetic drug carrier particles (MDCPs) using an external magnet is theoretically studied. Three magnetic drug targeting (MDT) systems are evaluated in terms of their MDCP collection efficiency (CE): a permanent magnet and wire is better than a permanent magnet alone, which is better than a homogeneous magnetic field and wire. (c) 2005 Published by Elsevier B.V.
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页码：605 / 615
页数：11
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