Etiologic factors in soft tissue sarcomas

被引：13

作者：

Froehner, M ^{[1
]}

Wirth, MP ^{[1
]}

机构：

[1] Tech Univ Dresden, Klinikum Carl Gustav Carus, Klin & Poliklin Urol, D-01307 Dresden, Germany

来源：

ONKOLOGIE | 2001年 / 24卷 / 02期

关键词：

soft tissue sarcoma; etiology; irradiation; inflammation; hormones;

D O I：

10.1159/000050301

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Soft tissue sarcomas account for about 1% of all maligna ncies. The increase in incidence of soft tissue sarcomas during the recent decades may predominantly be attributed to AIDS-related Kaposi's sarcoma; when this tumor is excluded, conclusive evidence for an age-adjusted increase is lacking. Beside the well investigated role of the human immunodeficiency virus 1 (HIV-1) and the human herpesvirus 8 (HHV-8) in the tumorigenesis of AIDS-related Kaposi's sarcoma and several inherited disorders, considerable evidence support a relationship between occupational chemicals as vinyl chloride, phenoxyacetic acid herbicides, chlorphenols, dioxin, medicinal measures as Thorotrast exposure and therapeutic irradiation, and the development of soft tissue sarcoma. Hormones and chronic repair processes are further probably sarcoma-promoting factors. Considering the rarity of soft tissue sarcomas despite the vast portion that soft tissues comprise in the human body, additional knowledge on the tumorigenesis of soft tissue sarcomas might considerably contribute to the understanding of the etiologic pathways of malignant tumors in humans.

引用

页码：139 / 142

页数：4

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