Modulation of mTORC1 Signaling Pathway by HIV-1

被引：28

作者：

Akbay, Burkitkan ^{[1
,2
]}

Shmakova, Anna ^{[1
,2
]}

Vassetzky, Yegor ^{[1
,2
,3
]}

Dokudovskaya, Svetlana ^{[1
,2
]}

机构：

[1] Univ Paris Saclay, Inst Gustave Roussy, CNRS, UMR 9018, 114 Rue Edouard Vaillant, F-94805 Villejuif, France

[2] LIA 1066 LFR2O French Russian Joint Canc Res Lab, 114 Rue Edouard Vaillant, F-94805 Villejuif, France

[3] Koltzov Inst Dev Biol, 26 Vavilova Str, Moscow 119334, Russia

来源：

CELLS | 2020年 / 9卷 / 05期

关键词：

HIV-1; HIV-1 related diseases; mTORC1; pathway; autophagy; PROTEIN-COUPLED RECEPTOR; REGULATORY T-CELLS; MAMMALIAN-TARGET; LATENCY REVERSAL; VIRAL RESERVOIRS; R5; STRAINS; RAPAMYCIN; AUTOPHAGY; ACTIVATION; AKT;

D O I：

10.3390/cells9051090

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of cellular proliferation and survival which controls cellular response to different stresses, including viral infection. HIV-1 interferes with the mTORC1 pathway at every stage of infection. At the same time, the host cells rely on the mTORC1 pathway and autophagy to fight against virus replication and transmission. In this review, we will provide the most up-to-date picture of the role of the mTORC1 pathway in the HIV-1 life cycle, latency and HIV-related diseases. We will also provide an overview of recent trends in the targeting of the mTORC1 pathway as a promising strategy for HIV-1 eradication.

引用

页数：17

共 139 条

[1] HIV "shock and kill" therapy: In need of revision [J].

Abner, Erik ;

Jordan, Albert .

ANTIVIRAL RESEARCH, 2019, 166 :19-34

[2] Autophagy-Virus Interplay: From Cell Biology to Human Disease [J].

Ahmad, Liyana ;

Mostowy, Serge ;

Sancho-Shimizu, Vanessa .

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2018, 6

[3] Inhibition of the CCL5/CCR5 Axis against the Progression of Gastric Cancer [J].

Aldinucci, Donatella ;

Casagrande, Naike .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (05)

[4] HIV-1 Vpr inhibits autophagy during the early steps of infection of CD4 T cells [J].

Alfaisal, Jamal ;

Machado, Alice ;

Galais, Mathilde ;

Robert-Hebmann, Veronique ;

Arnaune-Pelloquin, Laetitia ;

Espert, Lucile ;

Biard-Piechaczyk, Martine .

BIOLOGY OF THE CELL, 2019, 111 (12) :308-318

[5] mTOR regulates memory CD8 T-cell differentiation [J].

Araki, Koichi ;

Turner, Alexandra P. ;

Shaffer, Virginia Oliva ;

Gangappa, Shivaprakash ;

Keller, Susanne A. ;

Bachmann, Martin F. ;

Larsen, Christian P. ;

Ahmed, Rafi .

NATURE, 2009, 460 (7251) :108-U124

[6] ATM and ATR signaling at a glance (vol 128, pg 4255, 2015) [J].

Awasthi, Poorwa ;

Foiani, Marco ;

Kumar, Amit .

JOURNAL OF CELL SCIENCE, 2016, 129 (06) :1285-1285

[7] Efficacy of the oral mTORC1 inhibitor everolimus in relapsed or refractory indolent lymphoma [J].

Bennani, N. Nora ;

LaPlant, Betsy R. ;

Ansell, Stephen M. ;

Habermann, Thomas. M. ;

Inwards, David J. ;

Micallef, Ivana N. ;

Johnston, Patrick B. ;

Porrata, Luis F. ;

Colgan, Joseph P. ;

Markovic, Svetomir N. ;

Nowakowski, Grzegorz S. ;

Macon, William R. ;

Reeder, Craig B. ;

Mikhael, Joseph R. ;

Northfelt, Donald W. ;

Ghobrial, Irene M. ;

Witzig, Thomas E. .

AMERICAN JOURNAL OF HEMATOLOGY, 2017, 92 (05) :448-453

[8] The mTOR Complex Controls HIV Latency [J].

Besnard, Emilie ;

Hakre, Shweta ;

Kampmann, Martin ;

Lim, Hyung W. ;

Hosmane, Nina N. ;

Martin, Alyssa ;

Bassik, Michael C. ;

Verschueren, Erik ;

Battivelli, Emilie ;

Chan, Jonathan ;

Svensson, J. Peter ;

Gramatica, Andrea ;

Conrad, Ryan J. ;

Ott, Melanie ;

Greene, Warner C. ;

Krogan, Nevan J. ;

Siliciano, Robert F. ;

Weissman, Jonathan S. ;

Verdin, Eric .

CELL HOST & MICROBE, 2016, 20 (06) :785-797

[9] Human Immunodeficiency Virus-1 Inhibition of Immunoamphisomes in Dendritic Cells Impairs Early Innate and Adaptive Immune Responses [J].

Blanchet, Fabien P. ;

Moris, Arnaud ;

Nikolic, Damjan S. ;

Lehmann, Martin ;

Cardinaud, Sylvain ;

Stalder, Romaine ;

Garcia, Eduardo ;

Dinkins, Christina ;

Leuba, Florence ;

Wu, Li ;

Schwartz, Olivier ;

Deretic, Vojo ;

Piguet, Vincent .

IMMUNITY, 2010, 32 (05) :654-669

[10] The challenge of viral reservoirs in HIV-1 infection [J].

Blankson, JN ;

Persaud, D ;

Siliciano, RF .

ANNUAL REVIEW OF MEDICINE, 2002, 53 :557-593

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