Dating the age of admixture via wavelet transform analysis of genome-wide data

被引:59
|
作者
Pugach, Irina [1 ]
Matveyev, Rostislav [2 ]
Wollstein, Andreas [3 ,4 ]
Kayser, Manfred [4 ]
Stoneking, Mark [1 ]
机构
[1] Max Planck Inst Evolutionary Anthropol, D-04103 Leipzig, Germany
[2] Univ Leipzig, Inst Math, D-04009 Leipzig, Germany
[3] Univ Cologne, Cologne Ctr Genom, D-50931 Cologne, Germany
[4] Erasmus MC Univ Med Ctr Rotterdam, Dept Forens Mol Biol, NL-3000 CA Rotterdam, Netherlands
来源
GENOME BIOLOGY | 2011年 / 12卷 / 02期
关键词
POPULATION-STRUCTURE; ASSOCIATION; INFERENCE; ANCESTRY; SEQUENCE; MAP; SELECTION; PATTERNS; TOOL;
D O I
10.1186/gb-2011-12-2-r19
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
We describe a PCA-based genome scan approach to analyze genome-wide admixture structure, and introduce wavelet transform analysis as a method for estimating the time of admixture. We test the wavelet transform method with simulations and apply it to genome-wide SNP data from eight admixed human populations. The wavelet transform method offers better resolution than existing methods for dating admixture, and can be applied to either SNP or sequence data from humans or other species.
引用
收藏
页数:18
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