Plasminogen Activator Inhibitor-1 Polymorphism Confers a Genetic Contribution to the Risk of Recurrent Spontaneous Abortion: An Updated Meta-Analysis

被引：7

作者：

Huang, Zhan ^{[1
]}

Tang, Wenqian ^{[2
]}

Liang, Zhikun ^{[1
]}

Chen, Qiaopei ^{[1
]}

Li, Mingyi ^{[1
]}

Li, Yingfeng ^{[1
]}

Lao, Shaoxing ^{[1
]}

Pan, Huimin ^{[1
]}

Huang, Liying ^{[1
]}

Huang, Min ^{[1
]}

Hu, Xuehua ^{[1
]}

Zhao, Jiangyang ^{[1
]}

机构：

[1] Maternal & Child Hlth Hosp Guangxi Zhuang Autonom, Childrens Hosp, Dept Clin Lab, Nanning 530003, Guangxi, Peoples R China

[2] Guangxi Zhuang Autonomous Region Ctr Dis Control, Nanning, Guangxi, Peoples R China

来源：

REPRODUCTIVE SCIENCES | 2017年 / 24卷 / 11期

关键词：

plasminogen activator inhibitor-1; recurrent spontaneous abortion; polymorphism; meta-analysis; COAGULATION-FACTOR XIII; PREGNANCY LOSS; 4G/5G POLYMORPHISM; PAI-1; GENES; ACE I/D; MISCARRIAGE; MUTATIONS; ASSOCIATION; THROMBOPHILIA; WOMEN;

D O I：

10.1177/1933719117702013

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Various studies have investigated the risk of recurrent spontaneous abortion (RSA) with plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism. However, the results have been somewhat contradictory. Therefore, an updated meta-analysis based on 31 studies (5617 cases and 3952 controls) was undertaken to clarify this relationship. The degree of RSA risk was estimated using the odds ratio (OR) and the 95% confidence interval (CI). Overall, the random effects OR was 1.464 (95% CI: 1.269-1.690) for 4G versus 5G, 2.075 (95% CI: 1.563-2.754) for 4G/4G versus 5G/5G, 1.457 (95% CI: 1.211-1.753) for 4G/5G versus 5G/5G, 1.743 (95% CI: 1.358-2.236) for 4G/4G versus 4G/5G + 5G/5G, and 1.600 (95% CI: 1.327-1.930) for 4G/4G + 4G/5G versus 5G/5G, indicating that PAI-1 4G/5G polymorphism could confer an increased risk of RSA. Furthermore, a subgroup analysis showed a significantly elevated susceptibility to RSA in Asians, Caucasians, and Africans. Thus, this study demonstrated that PAI-1 4G/5G polymorphism likely confers a genetic contribution to the development of RSA. The results may aid in developing a theoretical basis for effective strategies to prevent and treat RSA.

引用

页码：1551 / 1560

页数：10

共 56 条

[1] Polymorphisms of plasminogen activator inhibitor-1, angiotensin converting enzyme and coagulation factor XIII genes in patients with recurrent spontaneous abortion [J].

Aarabi, Mahmoud ;

Memariani, Toktam ;

Arefi, Soheila ;

Aarabi, Mohsen ;

Zadeh, Sedigheh Hantoosh ;

Akhondi, Mehdi A. ;

Modarressi, Mohammad H. .

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 2011, 24 (03) :545-548

[2] Polymorphisms in NOS3, ACE and PAI-1 Genes and Risk of Spontaneous Recurrent Miscarriage in the Gaza Strip [J].

Al Sallout, Rami J. ;

Sharif, Fadel A. .

MEDICAL PRINCIPLES AND PRACTICE, 2010, 19 (02) :99-104

[3] Definitions of infertility and recurrent pregnancy loss: a committee opinion [J].

不详 .

FERTILITY AND STERILITY, 2013, 99 (01) :63-63

[4]

[Anonymous], MATERN CHILD HLTH CA

[5]

[Anonymous], CHIN J BIRTH HLTH HE

[6]

[Anonymous], 2016, CHIN J BIRTH HLTH HE

[7]

[Anonymous], THESIS

[8]

[Anonymous], CHIN J BIRTH HLTH HE

[9] Prevalence of thrombophilic gene polymorphisms in an Azari population of Iran [J].

Bargahi, Nasrin ;

Farajzadeh, Malak ;

Poursadegh-Zonouzi, Ahmad ;

Farajzadeh, Davoud .

HEMATOLOGY REPORTS, 2014, 6 (02) :16-18

[10] OPERATING CHARACTERISTICS OF A BANK CORRELATION TEST FOR PUBLICATION BIAS [J].

BEGG, CB ;

MAZUMDAR, M .

BIOMETRICS, 1994, 50 (04) :1088-1101

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