Nationwide surveillance of the antimicrobial susceptibility of Chlamydia trachomatis from male urethritis in Japan: Comparison with the first surveillance report

被引：4

作者：

Takahashi, Satoshi ^{[1
,2
,5
]}

Yasuda, Mitsuru ^{[1
,2
,11
]}

Wada, Koichiro ^{[1
,2
,14
]}

Matsumoto, Masahiro ^{[1
,2
,17
]}

Hayami, Hiroshi ^{[1
,2
,18
]}

Kobayashi, Kanao ^{[1
,2
]}

Miyazaki, Jun ^{[1
,2
]}

Kiyota, Hiroshi ^{[2
,3
,7
]}

Matsumoto, Tetsuya ^{[2
,3
]}

Yotsuyanagi, Hiroshi ^{[2
,3
]}

Tateda, Kazuhiro ^{[2
,3
]}

Sato, Junko ^{[2
,3
]}

Hanaki, Hideaki ^{[4
]}

Masumori, Naoya ^{[6
]}

Hiyama, Yoshiki ^{[6
]}

Egawa, Shin ^{[7
]}

Yamada, Hiroki ^{[8
]}

Matsumoto, Kazumasa ^{[9
]}

Ishikawa, Kiyohito ^{[10
]}

Yamamoto, Shingo ^{[12
]}

Togo, Yoshikazu ^{[12
]}

Tanaka, Kazushi ^{[13
]}

Shigemura, Katsumi ^{[13
]}

Uehara, Shinya ^{[14
]}

Kitano, Hiroyuki ^{[15
]}

Kiyoshima, Keijiro ^{[16
]}

Hamasuna, Ryoichi ^{[17
]}

Ito, Kenji ^{[19
]}

Hirayama, Hideo ^{[20
]}

Kawai, Shuichi ^{[21
]}

Shiono, Yutaka ^{[22
]}

Maruyama, Takahiro ^{[23
]}

Ito, Shin ^{[24
]}

Yoh, Mutsumasa ^{[25
]}

Ito, Masayasu ^{[26
]}

Hatano, Koichi ^{[27
]}

Ihara, Hideari ^{[28
]}

Uno, Satoshi ^{[29
]}

Monden, Koichi ^{[30
]}

Yokoyama, Teruhiko ^{[31
]}

Takayama, Kazuo ^{[32
]}

Sumii, Toru ^{[33
]}

Kadena, Hitoshi ^{[34
]}

Kawahara, Motoshi ^{[35
]}

Hosobe, Takahide ^{[36
]}

Izumitani, Masanobu ^{[37
]}

Kano, Motonori ^{[38
]}

Nishimura, Hirofumi ^{[39
]}

Fujita, Ryuji ^{[40
]}

Kaji, Shinichi ^{[41
]}

机构：

[1] Japanese Assoc Infect Dis JAID, Urogenital Subcomm & Surveillance Comm, Japanese Soc Chemotherapy JSC, Tokyo, Japan

[2] Japanese Soc Clin Microbiol JSCM, Tokyo, Japan

[3] JAID, JSC, Surveillance Comm, Tokyo, Japan

[4] Kitasato Univ, Infect Control Res Ctr, Tokyo, Japan

[5] Sapporo Med Univ, Dept Infect Control & Lab Med, Sch Med, Sapporo, Hokkaido, Japan

[6] Sapporo Med Univ, Dept Urol, Sch Med, Sapporo, Hokkaido, Japan

[7] Jikei Univ, Dept Urol, Sch Med, Tokyo, Japan

[8] Jikei Univ, Dept Urol, Katsushika MedicalCtr, Tokyo, Japan

[9] Kitasato Univ, Dept Urol, Sch Med, Sagamihara, Kanagawa, Japan

[10] Fujita Hlth Univ, Dept Urol, Toyoake, Aichi, Japan

[11] Gifu Univ, Grad Sch Med, Dept Urol, Gifu, Japan

[12] Hyogo Coll Med, Dept Urol, Nishinomiya, Hyogo, Japan

[13] Kobe Univ, Div Urol, Grad Sch Med, Kobe, Hyogo, Japan

[14] Okayama Univ, Dept Urol, Grad Sch Med Dent & Pharmaceut Sci, Okayama, Japan

[15] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Urol, Hiroshima, Japan

[16] Kyushu Univ, Grad Sch Med Sci, Dept Urol, Fukuoka, Japan

[17] Univ Occupat & Environm Hlth, Dept Urol, Kitakyushu, Fukuoka, Japan

[18] Kagoshima Univ Hosp, Blood Purificat Ctr, Kagoshima, Japan

[19] Ito Urol Clin, Kitakyushu, Fukuoka, Japan

[20] Hirayama Urol Clin, Kumamoto, Japan

[21] Kawai Urol Clin, Kitakyushu, Fukuoka, Japan

[22] Aioi 23 Clin, Yokohama, Kanagawa, Japan

[23] Maruyama Urol Clin, Nagoya, Aichi, Japan

[24] IClinic, Sendai, Miyagi, Japan

[25] Yoh Urol & Dermatol Clin, Inazawa, Japan

[26] Gifu Urol Clin, Gifu, Japan

[27] Hatano Urol & Dermatol Clin, Gifu, Japan

[28] Ihara Clin, Nishinomiya, Hyogo, Japan

[29] Hirajima Clin, Okayama, Japan

[30] Araki Urol Clin, Kurashiki, Okayama, Japan

[31] Yokoyama Urol Clin, Okayama, Japan

[32] Takayama Hosp, Dept Urol, Chikushino, Japan

[33] Sumii Clin, Hiroshima, Japan

[34] Kadena Urol Clin, Hiroshima, Japan

[35] Kawahara Urol Clin, Kagoshima, Japan

[36] Hosobe Clin, Tokyo, Japan

[37] Izumitani Fureai Urol Clin, Nagoya, Aichi, Japan

[38] Kano Hosp, Dept Urol, Fukuoka, Japan

[39] Nishimura Urol Clin, Kitakyushu, Fukuoka, Japan

[40] Jin Hinyokika Nishikawahara Clin, Okaayama, Japan

[41] Kaji Clin, Fukuoka, Japan

[42] Tomakomai Urol & Cardiol Clin, Tomakomai, Japan

[43] Tomeiatsugi Hosp, Dept Urol, Atsugi, Kanagawa, Japan

[44] Matsumura Urol Clin, Kato, Japan

来源：

JOURNAL OF INFECTION AND CHEMOTHERAPY | 2022年 / 28卷 / 01期

关键词：

Chlamydia trachomatis; Antimicrobial susceptibility; Surveillance; IN-VITRO SUSCEPTIBILITY; AZITHROMYCIN; DOXYCYCLINE;

D O I：

10.1016/j.jiac.2021.09.012

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The Urogenital Sub-committee and the Surveillance Committee of the Japanese Society of Chemotherapy, The Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology conducted the second nationwide surveillance of the antimicrobial susceptibility of Chlamydia trachomatis. In this second surveillance study, clinical urethral discharge specimens were collected from patients with urethritis in 26 hospitals and clinics from May 2016 to July 2017. Based on serial cultures, the minimum inhibitory concentration (MIC) could be determined for 41 isolates; the MICs (MIC90) of ciprofloxacin, levofloxacin, tosufloxacin, sitafloxacin, doxycycline, minocycline, erythromycin, clarithromycin, azithromycin and solithromycin were 2 mu g/ml (2 mu g/ml), 1 mu g/ml (0.5 mu g/ml), 0.25 mu g/ml (0.25 mu g/ml), 0.125 mu g/ml (0.063 mu g/ml), 0.125 mu g/ml (0.125 mu g/ml), 0.25 mu g/ml (0.25 mu g/ml), 0.031 mu g/ml (0.031 mu g/ml), 0.25 mu g/ml (0.125 mu g/ml), and 0.016 mu g/ml (0.008 mu g/ml), respectively. In summary, this surveillance project did not identify any strains resistant to fluoroquinolone, tetracycline, or macrolide agents in Japan. In addition, the MIC of solithromycin was favorable and lower than that of other antimicrobial agents. However, the MIC of azithromycin had a slightly higher value than that reported in the first surveillance report, though this might be within the acceptable margin of error. Therefore, the susceptibility of azithromycin, especially, should be monitored henceforth.

引用

页码：1 / 5

页数：5

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