Diagnostic Performance of Diffusion Tensor Imaging with Readout-segmented Echo-planar Imaging for Invasive Breast Cancer: Correlation of ADC and FA with Pathological Prognostic Markers

被引:30
作者
Yamaguchi, Ken [1 ]
Nakazono, Takahiko [1 ]
Egashira, Ryoko [1 ]
Komori, Yoshiaki [2 ]
Nakamura, Jun [3 ]
Noguchi, Tomoyuki [1 ,4 ]
Irie, Hiroyuki [1 ]
机构
[1] Saga Univ, Dept Radiol, Fac Med, 5-1-1 Nabeshima, Saga 8498501, Japan
[2] Siemens Japan KK Res & Collaborat Dept, Tokyo, Japan
[3] Saga Univ, Dept Surg, Fac Med, Saga, Japan
[4] Natl Ctr Global Hlth & Med NCGM, Dept Radiol, Tokyo, Japan
关键词
breast; MRI; diffusion-weighted imaging; readout-segmented echo planar imaging; diffusion tensor imaging; COEFFICIENT VALUES; DUCTAL CARCINOMA; MR MAMMOGRAPHY; 3.0; TESLA; LESIONS; 3T; PARAMETERS; WOMEN;
D O I
10.2463/mrms.mp.2016-0037
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: To assess the diagnostic performance of readout-segmented echo-planar diffusion tensor imaging (DTI based on rs-EPI) for breast cancer and to determine the correlation between the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values obtained from DTI based on rs-EPI with prognostic markers of invasive breast cancer. Materials and Methods: This retrospective study examined 80 pathologically proven breast lesions (22 benign and 58 malignant lesions) of 80 patients who underwent both diffusion-weighted imaging based on single-shot echo-planar imaging (DWI based on ss-EPI) and DTI based on rs-EPI with b-values of 0 and 1000. We identified and compared the diagnostic performances of the DWI based on ss-EPI and the DTI based on rs-EPI using ADCs by conducting a receiver-operating-characteristics (ROC) analysis. We determined the correlations between the ADCs and the prognostic markers and those of the FA values and the same markers. Results: The median ADCs of the benign and malignant lesions based on the ss-EPI were 1.57 and 1.2 x 10(-3) mm(2)/sec, and those based on the rs-EPI were 1.53 and 1.09 x 10(-3) mm(2)/sec, respectively. The area under the curve on the ROC analysis based on rs-EPI (0.924) was greater than that based on ss-EPI (0.897). There were no significant correlations between the ADCs and the prognostic markers, but there were significant correlations between the FA values and the estrogen receptor status, a proliferative marker, the nuclear grade and the intrinsic subtype. Conclusion: For breast cancer, DTI based on rs-EPI had superior diagnostic performance compared to DWI based on ss-EPI. Compared with the ADCs, the FA values were more closely correlated with prognostic markers of invasive breast cancer.
引用
收藏
页码:245 / 252
页数:8
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