Determination of Uric Acid in Biological Fluids by Ceria Nanoparticles Doped Reduced Graphene Oxide Nanocomposite Voltammetric Sensor

被引：21

作者：

Deng, Peihong ^{[1
,2
,3
,4
]}

Feng, Jinxia ^{[5
]}

Xiao, Jingyun ^{[5
]}

Wei, Yanping ^{[5
]}

Zuo, Jinsong ^{[5
]}

Li, Junhua ^{[1
,2
,3
,4
]}

Ding, Jianhua ^{[5
,6
]}

He, Quanguo ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Hengyang Normal Univ, Dept Chem & Mat Sci, Hengyang 421008, Peoples R China

[2] Univ Hunan Prov, Key Lab Funct Organomet Mat, Hengyang 421008, Peoples R China

[3] Key Lab Funct Metal Organ Cpds Hunan Province, Hengyang 421008, Peoples R China

[4] Key Lab Chem Sensing & Catalysis, Hengyang 421008, Peoples R China

[5] Hunan Univ Technol, Sch Life Sci & Chem, Zhuzhou 412007, Peoples R China

[6] Zhuzhou Peoples Hosp, Geriatr Rehabil Dept, Zhuzhou 421007, Peoples R China

来源：

JOURNAL OF THE ELECTROCHEMICAL SOCIETY | 2021年 / 168卷 / 12期

关键词：

PERFORMANCE LIQUID-CHROMATOGRAPHY; GLASSY-CARBON ELECTRODE; ASCORBIC-ACID; DOPAMINE; SERUM;

D O I：

10.1149/1945-7111/ac4376

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

High levels of uric acid (UA) in the human body usually cause diabetes, hypertension and atherosclerosis, kidney diseases, and neurological diseases. Hence, it is important to develop sensitive methods for UA determination. In this paper, nanocomposite composed of ceria nanoparticles and reduced graphene was successfully modified on the surface of glassy carbon electrode (ceria NPs-rGO/GCE) by a simple electroreduction method. The morphology, structure and property of the ceria NPs-rGO/GCE was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The electrocatalytic activity of the ceria NPs-rGO/GCE for uric acid (UA) oxidation was studied in detail. The results showed that the ceria NPs-rGO/GCE exhibited excellent selectivity and high sensitivity for UA detection. In 0.05 M H2SO4 solution, a linear range of 0.02-20 mu M and a low detection limit of 8.0 nM of UA were obtained on the ceria NPs-rGO/GCE. This developed method was successfully applied for the detection of UA in human serum and urine samples, and its recoveries reached 95.8%-105.0%. (C) 2021 The Electrochemical Society ("ECS"). Published on behalf of ECS by IOP Publishing Limited.

引用

页数：9

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