Computational identification of protein-coding sequences by comparative analysis

被引：1

作者：

Fontaine, Arnaud ^{[1
]}

Touzet, Helene ^{[1
]}

机构：

[1] Univ Lille 1, CNRS, UMR 8022, LIFL,INRIA Sequoia, F-59655 Villeneuve Dascq, France

来源：

2007 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE, PROCEEDINGS | 2007年

关键词：

D O I：

10.1109/BIBM.2007.11

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

Gene prediction is an essential step in understanding the genome of a species once it has been sequenced. For that, a promising direction in current research on gene finding is a comparative genomics approach. In this paper, we present a novel approach to identifying evolutionarily conserved protein-coding sequences in genomes. The method takes advantage of the specific substitution pattern of coding sequences together with the consistency of reading frames. It has been implemented in a software called Protea. Large-scale experimentation shows good results. Protea is intended to be a useful complement to existing tools based on homology search or statistical properties of the sequences.

引用

页码：95 / 102

页数：8

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