Healthy elderly Singaporeans show no age-related humoral hyporesponsiveness nor diminished plasmablast generation in response to influenza vaccine

被引：8

作者：

Camous, Xavier ^{[1
]}

Visan, Lucian ^{[2
]}

Ying, Crystal Tan Tze ^{[1
]}

Abel, Brian ^{[3
]}

Nyunt, Ma Shwe Zin ^{[4
]}

Narang, Vipin ^{[3
]}

Poidinger, Michael ^{[3
]}

Carre, Christophe ^{[2
]}

Sesay, Sanie ^{[5
]}

Bosco, Nabil ^{[6
]}

Burdin, Nicolas ^{[2
]}

Tambyah, Paul Anantharajah ^{[7
]}

Pin, Ng Tze ^{[4
]}

Larbi, Anis ^{[1
,3
]}

机构：

[1] Agcy Sci Technol & Res, Biol Aging Lab, Singapore Immunol Network, Singapore, Singapore

[2] Sanofi Pasteur, Res & Nonclin Safety, Marcy Letoile, France

[3] Agcy Sci Technol & Res, Immunomonitoring Platform, Singapore Immunol Network, 8A Biomed Grove, Singapore 138648, Singapore

[4] Natl Univ Singapore, Dept Psychol Med, Gerontol Res Programme, Singapore, Singapore

[5] Sanofi Pasteur, Clin Sci, Marcy Letoile, France

[6] Nestle Res Ctr Asia, 21 Biopolis Rd, Singapore, Singapore

[7] Natl Univ Hlth Syst, Dept Infect Dis, Singapore, Singapore

来源：

IMMUNITY & AGEING | 2018年 / 15卷

关键词：

Aging; Influenza vaccination; Stratification; Co-morbidity; FRAILTY; HOSPITALIZATIONS; PEOPLE;

D O I：

10.1186/s12979-018-0137-4

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Improving influenza vaccine efficacy is a priority to reduce the burden of influenza-associated morbidity and mortality. By careful selection of individuals based on health we show sustained response to influenza vaccination in older adults. Sustaining health in aging could be an important player in maintaining immune responses to influenza vaccination.Trial registrationNCT03266237. Registered 30 August 2017, https://clinicaltrials.gov/ct2/show/NCT03266237.

引用

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