Monosaccharide and disaccharide mimics: New molecular tools for biology and medicine

被引：0

作者：

Vogel, P ^{[1
]}

机构：

[1] Univ Lausanne, BCH, Chim Sect, CH-1015 Lausanne, Switzerland

来源：

CHIMIA | 2001年 / 55卷 / 04期

关键词：

anticancer vaccine; carbasugar; conduramine; C-disaccharide; glycosidase inhibitor; glycosyltransferase inhibitor; iminosugar; isolevoglucosenone; 'naked sugar'; pentahydroxyindolizidine;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Intercellular communication is governed by interactions between surface oligosaccharides and glycoproteins. The biosynthesis of these molecules involves glycosidations catalyzed by glycosyltransferases and hydrolysis of O-glycosyl linkages catalyzed by glycosidases. Monosaccharide and disaccharide mimics such as carbasugars, iminosugars and C-linked disaccharides can be glycosidase or glycosyltransferase inhibitors. They are leads as new drugs to treat infective diseases and cancer. The preparation of a conduramine, a pentahydroxyindolizidine, and two C-linked disaccharides are outlined.

引用

页码：359 / 365

页数：7