Genetic variation in homocysteine metabolism, cognition, and white matter lesions

被引：26

作者：

de Lau, Lonneke M. L. ^{[1
,2
]}

van Meurs, Joyce B. J. ^{[3
]}

Uitterlinden, Andre G. ^{[2
,3
]}

Smith, A. David ^{[4
]}

Refsum, Helga ^{[4
,5
]}

Johnston, Carole ^{[4
]}

Breteler, Monique M. B. ^{[2
]}

机构：

[1] Erasmus MC, Dept Neurol, NL-3000 CA Rotterdam, Netherlands

[2] Erasmus MC, Dept Epidemiol & Biostat, NL-3000 CA Rotterdam, Netherlands

[3] Erasmus MC, Dept Internal Med, NL-3000 CA Rotterdam, Netherlands

[4] OPTIMA, Dept Physiol Anat & Genet, Oxford, England

[5] Univ Oslo, Dept Nutr, Inst Basic Med Sci, Oslo, Norway

来源：

NEUROBIOLOGY OF AGING | 2010年 / 31卷 / 11期

关键词：

Homocysteine; SNP; Cognition; White matter lesions; RISK;

D O I：

10.1016/j.neurobiolaging.2008.10.004

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Several studies have shown an association between homocysteine concentration and cognitive performance or cerebral white matter lesions. However, variations in genes encoding for enzymes and other proteins that play a role in homocysteine metabolism have hardly been evaluated in relation to these outcome measures. In the population-based Rotterdam Scan Study, we examined the association of seven polymorphisms of genes involved in homocysteine metabolism (MTHFR 677C>T, MTHFR 1298A>C, RFC 80G>A, TC 776C>G, MTR 2756A>G, MTRR 66A > G, and CBS 844ins68) with plasma total homocysteine, cognitive performance, and cerebral white matter lesions among 1011 non-demented elderly participants. Of all the studied polymorphisms, only MTHFR 677C > T was associated with homocysteine concentration. No significant relationship was observed for any of the polymorphisms with cognitive performance or severity of cerebral white matter lesions. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：2020 / 2022

页数：3

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