Lignan glucoside from Sinopodophyllum emodi and its cytotoxic activity

被引：22

作者：

Zhao, Chang Qi ^{[1
]}

Zhu, Yan Yan ^{[1
]}

Chen, Shu Ying ^{[2
]}

Ogihara, Yukio ^{[3
]}

机构：

[1] Beijing Normal Univ, Beijing Key Lab Gene Engn Drugs & Biol Technol, Key Lab Cell Proliferat & Regulat Biol, Minist Educ,Coll Life Sci, Beijing 100875, Peoples R China

[2] Yunnan Agr Univ, Fac Agron & Biotechnol, Kunming 650201, Peoples R China

[3] Nagoya City Univ, Fac Pharmaceut Sci, Nagoya, Aichi 4678603, Japan

来源：

CHINESE CHEMICAL LETTERS | 2011年 / 22卷 / 02期

关键词：

Sinopodophyllum emodi; Berberidaceae; 4,5-Didemethylpodophyllotoxin 7 '-O-beta-D-glucopyranoside; Cytotoxicity; PODOPHYLLOTOXIN GLUCOSIDE; GLYCOSIDES;

D O I：

10.1016/j.cclet.2010.10.013

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new lignan glycoside was isolated from the n-butanol extract of the roots and rhizomes of Sinopodophyllum emodi. On the basis of spectral evidences, its structure was established and named as 4,5-didemethylpodophyllotoxin 7'-O-beta-D-glucopyranoside. This compound showed cytotoxicity against four human cancer cell lines (Hela, K562, SH-SY5Y and CNE) in vitro. (C) 2010 Chang Qi Zhao. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：181 / 184

页数：4

共 8 条

[1] ARYLTETRALIN LIGNANS FROM LINUM-FLAVUM AND LINUM-CAPITATUM [J].