Functions and dysfunctions of mitochondrial dynamics

被引：1074
作者：
Detmer, Scott A. [1 ]
Chan, David C. [1 ]
机构：
[1] CALTECH, Div Biol, Pasadena, CA 91125 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 11期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrm2275
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Recent findings have sparked renewed appreciation for the remarkably dynamic nature of mitochondria. These organelles constantly fuse and divide, and are actively transported to specific subcellular locations. These dynamic processes are essential for mammalian development, and defects lead to neuroclegenerative disease. But what are the molecular mechanisms that control mitochondrial dynamics, and why are they important for mitochondrial function? We review these issues and explore how defects in mitochondrial dynamics might cause neuronal disease.
引用
收藏
页码：870 / 879
页数：10
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