Chiral N-Heterocyclic Carbene Ligand Enabled Nickel(0)-Catalyzed Enantioselective Three-Component Couplings as Direct Access to Silylated Indanols

被引：44

作者：

Ahlin, Joachim S. E. ^{[1
]}

Cramer, Nicolai ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Lab Asymmetr Catalysis & Synth, Inst Chem Sci & Engn, EPFL SB ISIC LCSA,BCH 4305, CH-1015 Lausanne, Switzerland

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 13期

基金：

瑞士国家科学基金会;

关键词：

CATALYZED REDUCTIVE COUPLINGS; H BOND ACTIVATION; OLEFIN METATHESIS; RUTHENIUM CATALYSTS; ALLYLIC ALCOHOLS; COLEOPHOMONE-B; ALPHA-OLEFINS; NHC LIGAND; ALDEHYDES; SILANES;

D O I：

10.1021/acs.orglett.6b01492

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantioselective nickel(0)-catalyzed reductive three-component coupling between aromatic aldehydes, norbornenes, and silanes affords directly silyl-protected indanol derivatives. A new bulky chiral C-2-symmetric NHC (NHC = N-heterocyclic carbene) ligand basing on the 1,2-di(napthalen-1-yl)ethylene diamine backbone allows accessing the annulated products as single diastereoisomers in high enantioselectivity.

引用

页码：3242 / 3245

页数：4

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