Integration of retroviruses: A fine balance between efficiency and danger

被引:24
作者
Fischer, A [1 ]
Cavazzana-Calvo, M
机构
[1] Necker Univ Hosp, INSERM, Dept Pediat Immunol, Paris, France
[2] Necker Univ Hosp, INSERM, Res Unit 429, Paris, France
[3] Necker Univ Hosp, Biotherapy Dept, Paris, France
关键词
D O I
10.1371/journal.pmed.0020010
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:22 / 24
页数:3
相关论文
共 10 条
[1]   Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning [J].
Aiuti, A ;
Slavin, S ;
Aker, M ;
Ficara, F ;
Deola, S ;
Mortellaro, A ;
Morecki, S ;
Andolfi, G ;
Tabucchi, A ;
Carlucci, F ;
Marinello, E ;
Cattaneo, F ;
Vai, S ;
Servida, P ;
Miniero, R ;
Roncarolo, MG ;
Bordignon, C .
SCIENCE, 2002, 296 (5577) :2410-2413
[2]   Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease [J].
Cavazzana-Calvo, M ;
Hacein-Bey, S ;
Basile, CD ;
Gross, F ;
Yvon, E ;
Nusbaum, P ;
Selz, F ;
Hue, C ;
Certain, S ;
Casanova, JL ;
Bousso, P ;
Le Deist, F ;
Fischer, A .
SCIENCE, 2000, 288 (5466) :669-672
[3]  
Coffin J. M., 1997, RETROVIRUSES
[4]   LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1 [J].
Hacein-Bey-Abina, S ;
Von Kalle, C ;
Schmidt, M ;
McCcormack, MP ;
Wulffraat, N ;
Leboulch, P ;
Lim, A ;
Osborne, CS ;
Pawliuk, R ;
Morillon, E ;
Sorensen, R ;
Forster, A ;
Fraser, P ;
Cohen, JI ;
de Saint Basile, G ;
Alexander, I ;
Wintergerst, U ;
Frebourg, T ;
Aurias, A ;
Stoppa-Lyonnet, D ;
Romana, S ;
Radford-Weiss, I ;
Gross, F ;
Valensi, F ;
Delabesse, E ;
Macintyre, E ;
Sigaux, F ;
Soulier, J ;
Leiva, LE ;
Wissler, M ;
Prinz, C ;
Rabbitts, TH ;
Le Deist, F ;
Fischer, A ;
Cavazzana-Calvo, M .
SCIENCE, 2003, 302 (5644) :415-419
[5]   Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells [J].
Hematti, P ;
Hong, BK ;
Ferguson, C ;
Adler, R ;
Hanawa, H ;
Sellers, S ;
Holt, IE ;
Eckfeldt, CE ;
Sharma, Y ;
Schmidt, M ;
von Kalle, C ;
Persons, DA ;
Billings, EM ;
Verfaillie, CM ;
Nienhuis, AW ;
Wolfsberg, TG ;
Dunbar, CE ;
Calmels, B .
PLOS BIOLOGY, 2004, 2 (12) :2183-2190
[6]   Retroviral vector integration occurs in preferred genomic targets of human bone marrow-repopulating cells [J].
Laufs, S ;
Gentner, B ;
Nagy, KZ ;
Jauch, A ;
Benner, A ;
Naundorf, S ;
Kuehlcke, K ;
Schiedlmeier, B ;
Ho, AD ;
Zeller, WJ ;
Fruehauf, S .
BLOOD, 2003, 101 (06) :2191-2198
[7]   Murine leukemia induced by retroviral gene marking [J].
Li, ZX ;
Düllmann, J ;
Schiedlmeier, B ;
Schmidt, M ;
von Kalle, C ;
Meyer, J ;
Forster, M ;
Stocking, C ;
Wahlers, A ;
Frank, O ;
Ostertag, W ;
Kühlcke, K ;
Eckert, HG ;
Fehse, B ;
Baum, C .
SCIENCE, 2002, 296 (5567) :497-497
[8]   Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences [J].
Mitchell, RS ;
Beitzel, BF ;
Schroder, ARW ;
Shinn, P ;
Chen, HM ;
Berry, CC ;
Ecker, JR ;
Bushman, FD .
PLOS BIOLOGY, 2004, 2 (08) :1127-1137
[9]   HIV-1 integration in the human genome favors active genes and local hotspots [J].
Schröder, ARW ;
Shinn, P ;
Chen, HM ;
Berry, C ;
Ecker, JR ;
Bushman, F .
CELL, 2002, 110 (04) :521-529
[10]   Transcription start regions in the human genome are favored targets for MLV integration [J].
Wu, XL ;
Li, Y ;
Crise, B ;
Burgess, SM .
SCIENCE, 2003, 300 (5626) :1749-1751