The conformational behaviour of α,β-trehalose-like disaccharides and their C-glycosyl, imino-C-glycosyl and carbagalactose analogues depends on the chemical nature of the modification:: an NMR investigation

被引：18

作者：

García-Aparicio, V

Fernández-Alonso, MDC

Angulo, J

Asensio, JL

Cañada, FJ

Jiménez-Barbero, JI

Mootoo, DR

Cheng, XH

机构：

[1] CSIC, Dept Estructura & Func Proteinas, Madrid 28040, Spain

[2] CSIC, Inst Quim Organ, Madrid, Spain

[3] CSIC, Inst Invest Quim, Seville 28006, Spain

[4] CUNY Hunter Coll, New York, NY 10021 USA

来源：

TETRAHEDRON-ASYMMETRY | 2005年 / 16卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.tetasy.2004.11.072

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The conformational behaviour of beta-O-Gal-(1-->1)-alpha-Man 4 and the C-glycoside, carbaglycoside and aza-C-glycoside mimics 1-3 has been studied using J/NOE NMR data, molecular mechanics and molecular dynamics. It is shown that the population distributions around the glycosidic linkages of the different analogues depend on the chemical nature of the acetal or pseudoacetal residue. (C) 2004 Published by Elsevier Ltd.

引用

页码：519 / 527

页数：9