Geriatric Conditions and Prescription of Vitamin K Antagonists vs. Direct Oral Anticoagulants Among Older Patients With Atrial Fibrillation: SAGE-AF

被引:10
作者
McManus, David D. [1 ,2 ]
Kiefe, Catarina [1 ]
Lessard, Darleen [1 ,2 ]
Waring, Molly E. [3 ]
Parish, David [4 ]
Awad, Hamza H. [4 ]
Marino, Francesca [2 ]
Helm, Robert [5 ]
Sogade, Felix [6 ]
Goldberg, Robert [1 ]
Hayward, Robert [7 ]
Gurwitz, Jerry [8 ]
Wang, Weijia [2 ]
Mailhot, Tanya [9 ,10 ]
Barton, Bruce [1 ]
Saczynski, Jane [9 ]
机构
[1] Univ Massachusetts, Sch Med, Dept Populat & Quantitat Hlth Sci, Worcester, MA 01655 USA
[2] Univ Massachusetts, Sch Med, Dept Med, Cardiol Div, Worcester, MA 01655 USA
[3] Univ Connecticut, Dept Allied Hlth Sci, Mansfield, MA USA
[4] Mercer Univ, Sch Med, Dept Community Med Intemal Med, Macon, GA 31207 USA
[5] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA
[6] Mercer Univ, Sch Med, Dept Med, Macon, GA 31207 USA
[7] Kaiser Permanente, Santa Clara Med Ctr, Dept Electrophysiol, Santa Clara, CA USA
[8] Univ Massachusetts, Sch Med, Div Geriatr Med, Worcester, MA USA
[9] Northeastern Univ, Dept Pharm & Hlth Syst Sci, Boston, MA 02115 USA
[10] Montreal Heart Inst Res Ctr, Montreal, PQ, Canada
来源
FRONTIERS IN CARDIOVASCULAR MEDICINE | 2019年 / 6卷
关键词
atrial fibrillation; anticoagulation; frailty; social isolation; older adults; MYOCARDIAL-INFARCTION; BLEEDING RISK; MORTALITY; DEPRESSION; WARFARIN; STROKE; SYMPTOMS; TRENDS; PREVENTION; MANAGEMENT;
D O I
10.3389/fcvm.2019.00155
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Geriatric conditions are common among patients with atrial fibrillation (AF) and relate to complications of oral anticoagulation (OAC). Objective: To examine the prevalence of geriatric conditions among older patients with AF on OAC and relate type of OAC to geriatric conditions. Methods: Participants had a diagnosis of AF, were aged >= 65 years, CHA(2)DS(2)VASC >= 2, and had no OAC contraindications. Participants completed a 6-component geriatric assessment that included validated measures of frailty (CHS Frailty Scale), cognitive function (MoCA), social support (MOS), depressive symptoms (PHQ9), vision, and hearing. Type of OAC prescribed was documented in medical records. Results: 86% of participants were prescribed an OAC. These participants were on average aged 75.7 (SD: 7.1) years, 49% were women, two thirds were frail or pre-frail, and 44% received a DOAC. DOAC users were younger, had lower CHA(2)DS(2)VASC and HAS-BLED scores, and were less likely to be frail. In Massachusetts, pre-frailty was associated with a significantly lower odds of DOAC vs. VKA use (OR = 0.64, 95%CI 0.45, 0.91). Pre-frailty (OR = 0.33, 95%CI 0.18-0.59) and social isolation (OR = 0.38, 95%CI 0.14-0.99) were associated with lower odds of DOAC receipt in patients aged 75 years or older. Social isolation was associated with higher odds of DOAC use (OR = 2.13, 95%CI 1.05-4.29) in patients aged 65-74 years. Conclusions: Geriatric conditions were common and related to type of OAC prescribed, differentially by age group. Research is needed to evaluate whether a geriatric examination can be used clinically to better inform OAC decision-making in older patients with AF.
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页数:8
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