Gut Microbial-Related Choline Metabolite Trimethylamine-N-Oxide Is Associated With Progression of Carotid Artery Atherosclerosis in HIV Infection

被引：40

作者：

Shan, Zhilei ^{[1
,2
]}

Clish, Clary B. ^{[3
]}

Hua, Simin ^{[4
]}

Scott, Justin M. ^{[3
]}

Hanna, David B. ^{[4
]}

Burk, Robert D. ^{[4
]}

Haberlen, Sabina A. ^{[5
]}

Shah, Sanjiv J. ^{[7
]}

Margolick, Joseph B. ^{[6
]}

Sears, Cynthia L. ^{[8
]}

Post, Wendy S. ^{[5
,8
]}

Landay, Alan L. ^{[9
]}

Lazar, Jason M. ^{[10
]}

Hodis, Howard N. ^{[11
]}

Anastos, Kathryn ^{[4
]}

Kaplan, Robert C. ^{[12
]}

Qi, Qibin ^{[4
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Nutr & Food Hyg, Wuhan, Hubei, Peoples R China

[2] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA

[3] Broad Inst Massachusetts Inst Technol & Harvard, Cambridge, MA USA

[4] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, 1300 Morris Pk Ave, Bronx, NY 10467 USA

[5] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[6] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA

[7] Northwestern Univ, Feinberg Sch Med, Dept Med, Div Cardiol, Chicago, IL 60611 USA

[8] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD USA

[9] Rush Univ, Med Ctr, Dept Immunol & Microbiol, Chicago, IL 60612 USA

[10] Suny Downstate Med Ctr, Dept Med, Brooklyn, NY 11203 USA

[11] Univ Southern Calif, Keck Sch Med, Div Cardiovasc Med, Los Angeles, CA USA

[12] Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, 1124 Columbia St, Seattle, WA 98104 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2018年 / 218卷 / 09期

关键词：

trimethylamine-N-oxide; choline metabolites; carotid atherosclerosis; HIV infection; risk factors; CARDIOVASCULAR-DISEASE; PHOSPHATIDYLCHOLINE; INFLAMMATION; BIOMARKERS; ACTIVATION; BURDEN; MARKER; PLAQUE; RISK;

D O I：

10.1093/infdis/jiy356

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We examined associations of 5 plasma choline metabolites with carotid plaque among 520 HIV-infected and 217 HIV-uninfected participants (112 incident plaque cases) over 7 years. After multivariable adjustment, higher gut microbiota-related metabolite trimethylamine-N-oxide (TMAO) was associated with an increased risk of carotid plaque in HIV-infected participants (risk ratio = 1.25 per standard deviation increment; 95% confidence interval, 1.05-1.50; P = .01). TMAO was positively correlated with biomarkers of monocyte activation and inflammation (sCD14, sCD163). Further adjustment for these biomarkers attenuated the association between TMAO and carotid plaque (P = .08). Among HIV-infected individuals, plasma TMAO was associated with carotid atherosclerosis progression, partially through immune activation and inflammation.

引用

页码：1474 / 1479

页数：6

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