Resolvins: Emerging Players in Autoimmune and Inflammatory Diseases

被引:72
作者
Abdolmaleki, Fereshte [1 ]
Kovanen, Petri T. [2 ]
Mardani, Rajab [3 ]
Gheibi-hayat, Seyed Mohammad [4 ]
Bo, Simona [5 ]
Sahebkar, Amirhossein [6 ,7 ,8 ]
机构
[1] Qazvin Univ Med Sci, Sch Paramed Sci, Cellular & Mol Res Ctr, Qazvin, Iran
[2] Wihuri Res Inst, Helsinki, Finland
[3] Pasteur Inst Iran, Dept Biochem, Tehran, Iran
[4] Shahid Sadoughi Univ Med Sci, Sch Med, Dept Genet, Yazd, Iran
[5] Univ Turin, AOU Citta Salute & Sci Torino, Dept Med Sci, Turin, Italy
[6] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Razavi Khorasan, Iran
[7] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad 9177948564, Razavi Khorasan, Iran
[8] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran
关键词
Autoimmune diseases; Resolution of inflammation; Resolvins; Specialized pro-resolving mediators; NEUTROPHIL EXTRACELLULAR TRAPS; PRORESOLVING LIPID MEDIATORS; ANTIINFLAMMATORY PROPERTIES; APOPTOTIC CELLS; PROTECTS MICE; AJULEMIC ACID; TGF-BETA; RESOLUTION; RECEPTOR; LIPOXINS;
D O I
10.1007/s12016-019-08754-9
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Resolvins, belonging to the group of specialized proresolving mediators (SPMs), are metabolic products of omega-3 polyunsaturated fatty acids (omega-3 PUFAs) and are synthesized during the initial phases of acute inflammatory responses to promote the resolution of inflammation. Resolvins are produced for termination of neutrophil infiltration, stimulation of the clearance of apoptotic cells by macrophages, and promotion of tissue remodeling and homeostasis. Metabolic dysregulation due to either uncontrolled activity of pro-inflammatory responses or to inefficient resolution of inflammation results in chronic inflammation and may also lead to atherosclerosis or other chronic autoimmune diseases such as rheumatoid arthritis, psoriasis, systemic lupus erythematosus, vasculitis, inflammatory bowel diseases, and type 1 diabetes mellitus. The pathogenesis of such diseases involves a complex interplay between the immune system and, environmental factors (non-infectious or infectious), and critically depends on individual susceptibility to such factors. In the present review, resolvins and their roles in the resolution of inflammation, as well as the role of these mediators as potential therapeutic agents to counteract specific chronic autoimmune and inflammatory diseases are discussed.
引用
收藏
页码:82 / 91
页数:10
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