Relationships between sleep quality and brain volume, metabolism, and amyloid deposition in late adulthood

被引：125

作者：

Branger, Pierre ^{[1
,2
,3
,4
]}

Arenaza-Urquijo, Eider M. ^{[1
,2
,3
,5
]}

Tomadesso, Clemence ^{[1
,2
,3
,5
]}

Mezenge, Florence ^{[1
,2
,3
,5
]}

Andre, Claire ^{[1
,2
,3
,5
]}

de Flores, Robin ^{[1
,2
,3
,5
]}

Mutlu, Justine ^{[1
,2
,3
,5
]}

de La Sayette, Vincent ^{[1
,2
,3
,4
]}

Eustache, Francis ^{[1
,2
,3
,5
]}

Chetelat, Gael ^{[1
,2
,3
,5
]}

Rauchs, Geraldine ^{[1
,2
,3
,5
]}

机构：

[1] INSERM, GIP Cyceron, U1077, F-14000 Caen, France

[2] Ecole Prat Hautes Etud, UMR S1077, F-14000 Caen, France

[3] Univ Caen Normandy, UMR S1077, F-14000 Caen, France

[4] Caen Univ Hosp, Dept Neurol, F-14000 Caen, France

[5] Caen Univ Hosp, U1077, F-14000 Caen, France

来源：

NEUROBIOLOGY OF AGING | 2016年 / 41卷

关键词：

Sleep; Amyloid; Neuroimaging; Florbetapir; Alzheimer disease; MILD COGNITIVE IMPAIRMENT; NREM SLOW WAVES; ALZHEIMERS-DISEASE; DEPENDENT MEMORY; APOLIPOPROTEIN-E; BETA-DEPOSITION; POOR SLEEP; DECLINE; WAKE; DISTURBANCES;

D O I：

10.1016/j.neurobiolaging.2016.02.009

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Recent studies in mouse models of Alzheimer's disease (AD) and in humans suggest that sleep disruption and amyloid-beta (A beta) accumulation are interrelated, and may, thus, exacerbate each other. We investigated the association between self-reported sleep variables and neuroimaging data in 51 healthy older adults. Participants completed a questionnaire assessing sleep quality and quantity and underwent positron emission tomography scans using [F-18]florbetapir and [F-18]fluorodeoxyglucose and an magnetic resonance imaging scan to measure A beta burden, hypometabolism, and atrophy, respectively. Longer sleep latency was associated with greater A beta burden in prefrontal areas. Moreover, the number of nocturnal awakenings was negatively correlated with gray matter volume in the insular region. In asymptomatic middle-aged and older adults, lower self-reported sleep quality was associated with greater A beta burden and lower volume in brain areas relevant in aging and AD, but not with glucose metabolism. These results highlight the potential relevance of preserving sleep quality in older adults and suggest that sleep may be a factor to screen for in individuals at risk for AD. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：107 / 114

页数：8

共 65 条

[1] Reduced Orbitofrontal and Parietal Gray Matter in Chronic Insomnia: A Voxel-Based Morphometric Study [J].